Monthly Archives: September 2012

IgA pemphigus associated with diffuse large B-cell lymphoma showing unique reactivity with desmocollins: Unusual clinical and histopathological features.

Authors: Asahina A, Koga H, Suzuki Y, Hashimoto T Abstract IgA pemphigus includes subcorneal pustular dermatosis (SPD)-type and intraepidermal neutrophilic IgA dermatosis (IEN)-type. Cases of IgG/IgA pemphigus have recently been documented(1) . Nonetheless, individual reports of IgA pemphigus indicate considerable

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Study of oral, ear, nose and throat involvement in pemphigus vulgaris by endoscopic examination.

Background:  Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. There are two different clinical forms: mucocutaneous (MCPV) or mucosal (MPV). However, it is not clear how PV

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Association between HLA-DRB1 polymorphisms and pemphigus vulgaris: a meta-analysis

Background  Several studies have reported that HLA-DRB1 may be correlated with pemphigus vulgaris (PV), but most have been based on small samples and the results remain inconsistent and unclear. Objectives  To investigate the correlation between DRB1 and PV by a

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Autoantibody detection in bullous pemphigoid: Clinical evaluation of the EUROPLUS™ Dermatology Mosaic.

Bullous pemphigoid (BP) is an autoimmune blistering skin disease. Autoantibodies to BP180 and BP230 can be detected by indirect immunofluorescence (IIF) on different substrates (oesophagus, salt-split-skin, BP180-antigen dots, BP230-transfected cells) and ELISA. Here, we compared test characteristics of these test

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Diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-skin autoantibodies in autoimmune blistering skin diseases: A systematic review and meta-analysis.

Abstract BACKGROUND: Systematic reviews and meta-analysis are essential tools to accurately and reliably summarize evidence, and can be used as a starting point for developing practice guidelines for the diagnosis and treatment of patients. AIM: To estimate the diagnostic accuracy

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