Paraneoplastic pemphigus (PNP), a clinically and immunopathologically distinct mucocutaneous blistering dermatosis, is a severe form of autoimmune multiorgan syndrome generally associated with poor therapeutic outcome and high mortality. This IgG-mediated disease is initiated by an obvious or occult lymphoproliferative disorder…
Blog Archives
Paraneoplastic Pemphigus: A Paraneoplastic Autoimmune Multiorgan Syndrome or Autoimmune Multiorganopathy?
Tagged with: autoimmune, paraneoplastic pemphigus, pemphigus, PNP
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Localized pemphigus with vegetative features
We present a 58-year-old Jamaican man with an eight-month history of an isolated, vegetative, eroded, and crusted plaque on the posterior aspect of the scalp. One month prior to referral to the Charles C. Harris Skin and Cancer Pavilion he…
Tagged with: IgG, Jamaica, localized pemphigus, pemphigus, pemphigus vulgaris, vegetative
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Biochip Technology for the Serological Diagnosis of Bullous Pemphigoid
Bullous pemphigoid is an autoimmune blistering skin disease characterized by the presence of circulating autoantibodies which recognize specific proteins of the epidermis and dermoepidermal junction. Diagnosis is based on clinical criteria and laboratory investigations, notably histology, direct and indirect immunofluorescence,…
Tagged with: anti-BP180, anti-BP230, antigen, autoantibodies, biochip, bullous pemphigoid, ELISA
Posted in Around the Globe, News and Information, Technolgy
Posted in Around the Globe, News and Information, Technolgy
Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris
There are a limited number of reports indicating the role of human leukocyte antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty…
Tagged with: class I alleles, haplotype, human leukocyte antigen, Iranian patients, pemphigus vulgaris
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Pemphigus and Pemphigoid in Domestic Animals: An Overview
Pemphigus and pemphigoid are uncommon dermatological entities in domestic animals and of a presumed autoimmune nature. In one form or another, they have been reported in the dog, cat, horse and goat. Although these diseases are considered to be…
Equine Pemphigus Foliaceus
Pemphigus foliaceus (pem-fi-gus foli-a-shus) is an auto immune disease that affects humans and dogs and, to a lesser extent, cats and horses. In horses, it is characterized by primary lesions that often begin on the head and lower extremities; secondary…
Tagged with: equine, horse, pemphigus, pemphigus foliaceus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the…
Tagged with: autoantibodies, cross-reactivity, desmosomes, pemphigus, pemphigus erythematosus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Feline Pemphigus Foliaceus
Pemphigus foliaceus (PF) is an immune-mediated disease that causes pustules and crusted lesions, most commonly on the pinnae, nasal planum, periocular area, chin, feet of affected cats. Acantholytic cells caused by dehydration of intercellular adhesions are often seen on cytology…
Tagged with: cat, feline, pemphigus, pemphigus foliaceus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Skin Disease, Autoimmune (Pemphigus) in Dogs
Pemphigus in Dogs Pemphigus is the general designation for a group of autoimmune skin diseases involving ulceration and crusting of the skin, as well as the formation of fluid-filled sacs and cysts (vesicles), and pus filled lesions (pustules). Some types…
The incidence of internal malignancies in pemphigus and bullous pemphigoid in Japan.
To evaluate the significance of the association of malignancy with autoimmune blistering diseases, we studied the incidence of internal malignancies in pemphigus and bullous pemphigoid based upon 496 cases of pemphigus and 1113 cases of bullous pemphigoid in Japan. Results…
