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Varicella-zoster virus (VZV) and alpha 1 antitrypsin: A Fatal Outcome in a patient affected by endemic pemphigus foliaceus

Herpes virus infections are well known infectious complications of pemphigus and bullous pemphigoid. We describe pathologic findings utilizing autopsy tissue from several organs from a patient affected by a new variant of endemic pemphigus in El Bagre, Colombia, South America.

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Posted in Clinical Research, Medical, News and Information

Study of Oral, Ear, Nose and Throat Involvement in Pemphigus Vulgaris by Endoscopic Examination

Background:  Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. There are two different clinical forms: mucocutaneous (MCPV) or mucosal (MPV). However, it is not clear how PV

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Posted in Clinical Research, Medical, News and Information

Autoantibody Detection in Bullous Pemphigoid: Clinical Evaluation of the EUROPLUS™ Dermatology Mosaic

Bullous pemphigoid (BP) is an autoimmune blistering skin disease. Auto-antibodies to BP180 and BP230 can be detected by indirect immunofluorescence (IIF) on different substrates (oesophagus, salt-split-skin, BP180-antigen dots, BP230-transfected cells) and ELISA. Here, we compared test characteristics of these test

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Posted in Around the Globe, Medical, News and Information

Results of Survey on Drugs Used to Treat Pemphigus

By Rebecca Berman, Janet Segall and Jean-Claude Bystryn, M.D. from The National Pemphigus Foundation and The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY. February 17, 1999 As many of you know, we

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Posted in Medical

Side-effects of intravenous immune globulins.

Intravenous immune globulin (IVIG) preparations are efficacious and safe products in use world-wide. Although rare, side-effects of IVIG may be serious, even life-threatening, and clinicians should be aware of their potential occurrence. The clinical benefit of immune globulin prophylaxis in

Posted in Medical

Registry Advocacy

IPPF MAB member Dr. Ani Sinha discusses the importance of a disease registry

Posted in Medical, P-P Patient Registry, Registry-based Research

Walking the CER Path

Hippocrates must be turning in his grave.

Posted in Medical

What Does the Future Hold For Disease Management?

DM programs will have amazing patient-monitoring technology at their call. The challenge will be to make good use of the data.

Posted in Medical

Association between desmoglein 3 haplotypes and PV

Background Pemphigus vulgaris (PV, OMIM 169610) is a severe blistering disorder of the skin and mucous membranes, caused by the production of autoantibodies directed against the epithelial adhesive protein desmoglein 3. Although an association between PV and HLA class II

Posted in Medical

Regulatory T Cells Are Severely Reduced in PV

This new study, published in the journal "Dermatology", shows that a severe reduction of T (Treg) cells may be involved in the pathogenesis of pemphigus vulgaris (PV), an autoimmune blistering disease.

Posted in Medical

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