Blog Archives

Bullous pemphigoid and internal diseases – A case-control study.

Posted on May 26, 2013 by Cristo Rey Intern

To study associations of bullous pemphigoid (BP) with internal diseases, we conducted a retrospective case control study assessing the frequency of selected diseases – diabetes mellitus, neurological diseases, malignant tumors, benign prostate hyperplasia, hypertension and ischemic heart disease in patients…

Targeted Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand To Keratinocytes with A Pemphigus Monoclonal Antibody

Posted on May 22, 2013 by Cristo Rey Intern

We determined the feasibility of using an anti-desmoglein (Dsg) monoclonal antibody, Px44, to deliver a biologically active protein to keratinocytes. Recombinantly produced Px44-green fluorescent protein (GFP) injected into mice and skin organ culture delivered GFP to the cell surface of…

The frequency of osteoporosis in patients with pemphigus vulgaris on treatment

Posted on May 14, 2013 by Cristo Rey Intern

Background: Pemphigus vulgaris was almost fatal before the advent of glucocorticoids. Unfortunately, the high doses and prolonged administration of glucocorticoids, which often needed to control the disease, result in numerous adverse effects many of which are serious. Aims: To evaluate the patients…

Tagged with: glucocorticoids, osteoporosis, pemphigus
Posted in Around the Globe, News and Information

Resistant oral mucosal lesions in pemphigus vulgaris responsive to double filtration plasmapheresis: First case report from Turkey.

Posted on May 10, 2013 by Cristo Rey Intern

Background Adjuvant therapeutic methods are employed when pemphigus vulgaris (PV) fails to be controlled by conventional corticosteroid treatment. Objective: The efficacy of double filtration plasmapheresis (DFPP) was investigated in a PV patient with severe, refractory mucosal disease. Methods A total…

Tagged with: Double filtration plasmapheresis, pemphigus vulgaris
Posted in Around the Globe, News and Information

Prevalence and Clinical Significance of Anti-Laminin 332 Autoantibodies Detected by a Novel Enzyme-Linked Immunosorbent Assay in Mucous Membrane Pemphigoid

Posted on May 8, 2013 by Cristo Rey Intern

IMPORTANCE A rare variant of mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 (Lam332) autoantibodies and seems to be associated with concurrent malignant neoplasms. OBJECTIVE To determine the prevalence and clinical significance of anti-Lam332 autoantibody detection from a large…

Tagged with: Anti-Laminin 332, autoantibodies, Autoimmune bullous diseases
Posted in Around the Globe, News and Information

Desmosomal adhesion and pemphigus vulgaris: the first half of the story

Posted on May 8, 2013 by Cristo Rey Intern

Pemphigus vulgaris (PV) is a paradigm of autoimmune disease affecting intercellular adhesion. The mechanisms that lead to cell–cell detachment (acantholysis) have crucial therapeutic implications and are currently undergoing major scrutiny. The first part of this review focuses on the classical…

Tagged with: desmogleins, IgG, pemphigus, pemphigus vulgaris
Posted in News and Information

Oxidative stress and autoimmune skin disease.

Posted on May 4, 2013 by Cristo Rey Intern

Antioxidants play the important role in our body of neutralizing free radicals and peroxides that are formed during normal physiologic events. While these reactive oxygen species are necessary for numerous biological processes, when created in excess they can have deleterious…

Application for Tacrolimus Ointment in Treating Refractory Inflammatory Ocular Surface Diseases

Posted on April 26, 2013 by Cristo Rey Intern

Purpose To evaluate the therapeutic effects of topical tacrolimus ointment on refractory inflammatory ocular surface diseases. Design Retrospective interventional consecutive case series. Methods In Severance Hospital, Seoul, South Korea, 0.02% tacrolimus ointment was topically applied 1 to 3 times per…

An attempt to develop mouse model for anti-laminin γ1 pemphigoid.

Posted on April 16, 2013 by Cristo Rey Intern

BACKGROUND: We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. However, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding…

Tagged with: anti-laminin, bunny, mice, mouse, rabbit
Posted in Around the Globe, News and Information

Lobar torsion after lung transplantation

Posted on April 10, 2013 by Cristo Rey Intern

Lobar torsion is a rare complication after lung transplantation. Here we report a case of right middle lobe (RML) torsion after bilateral sequential lung transplantation (BLTx). This 30-year-old lady underwent BLTx for bronchiolitis obliterans due to paraneoplastic pemphigus. The right…