Paraneoplastic pemphigus (PNP), a clinically and immunopathologically distinct mucocutaneous blistering dermatosis, is a severe form of autoimmune multiorgan syndrome generally associated with poor therapeutic outcome and high mortality. This IgG-mediated disease is initiated by an obvious or occult lymphoproliferative disorder…
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Paraneoplastic Pemphigus: A Paraneoplastic Autoimmune Multiorgan Syndrome or Autoimmune Multiorganopathy?
Tagged with: autoimmune, paraneoplastic pemphigus, pemphigus, PNP
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Biochip Technology for the Serological Diagnosis of Bullous Pemphigoid
Bullous pemphigoid is an autoimmune blistering skin disease characterized by the presence of circulating autoantibodies which recognize specific proteins of the epidermis and dermoepidermal junction. Diagnosis is based on clinical criteria and laboratory investigations, notably histology, direct and indirect immunofluorescence,…
Tagged with: anti-BP180, anti-BP230, antigen, autoantibodies, biochip, bullous pemphigoid, ELISA
Posted in Around the Globe, News and Information, Technolgy
Posted in Around the Globe, News and Information, Technolgy
Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris
There are a limited number of reports indicating the role of human leukocyte antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty…
Tagged with: class I alleles, haplotype, human leukocyte antigen, Iranian patients, pemphigus vulgaris
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Equine Pemphigus Foliaceus
Pemphigus foliaceus (pem-fi-gus foli-a-shus) is an auto immune disease that affects humans and dogs and, to a lesser extent, cats and horses. In horses, it is characterized by primary lesions that often begin on the head and lower extremities; secondary…
Tagged with: equine, horse, pemphigus, pemphigus foliaceus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the…
Tagged with: autoantibodies, cross-reactivity, desmosomes, pemphigus, pemphigus erythematosus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Feline Pemphigus Foliaceus
Pemphigus foliaceus (PF) is an immune-mediated disease that causes pustules and crusted lesions, most commonly on the pinnae, nasal planum, periocular area, chin, feet of affected cats. Acantholytic cells caused by dehydration of intercellular adhesions are often seen on cytology…
Tagged with: cat, feline, pemphigus, pemphigus foliaceus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Skin Disease, Autoimmune (Pemphigus) in Dogs
Pemphigus in Dogs Pemphigus is the general designation for a group of autoimmune skin diseases involving ulceration and crusting of the skin, as well as the formation of fluid-filled sacs and cysts (vesicles), and pus filled lesions (pustules). Some types…
A Possible Use of Cholinergic Drugs in Pemphigus Vulgaris
Human epidermis shows a non-neuronal cholinergic system including keratinocyte (kc) acetylcholine (Ach) axis which is composed by enzymes and two families of Ach receptors (muscarinic and nicotinic receptors). The activity of these two receptors can regulate the interkeratinocytes and kcs-extracellular…
Tagged with: acantholysis, cholinergic drugs, cholinergic system in keratinocytes cells, pemphigus vulgaris
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Recognizing Pyoderma:
Although bacterial pyoderma is among the most commonly encountered dermatologic conditions in dogs, some cases present diagnostic challenges even to experienced clinicians. This article presents several unusual manifestations of pyoderma, including bullous impetigo, superficial spreading pyoderma, mucocutaneous pyoderma, and post-grooming…
Tagged with: Bacterial culture, Bacterial overgrowth, Canine pyoderma, Cytology, Furunculosis, Impetigo, mucocutaneous, Staphylococcus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Study of apoptosis in oral pemphigus vulgaris
Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease presenting clinically with blisters or erosions of the skin and mucous membrane. The main histopathologic characteristic of this disease is suprabasal vesicles due to loss of cell–cell adhesion between keratinocytes named acantholysis.…
