Blog-Archive

Prevalence and Clinical Significance of Anti-Laminin 332 Autoantibodies Detected by a Novel Enzyme-Linked Immunosorbent Assay in Mucous Membrane Pemphigoid

Veröffentlicht am May 8, 2013 von Cristo Rey Intern

IMPORTANCE A rare variant of mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 (Lam332) autoantibodies and seems to be associated with concurrent malignant neoplasms. OBJECTIVE To determine the prevalence and clinical significance of anti-Lam332 autoantibody detection from a large…

Getagged mit: Anti-Laminin 332, autoantibodies, Autoimmune bullous diseases
Veröffentlicht unter Around the Globe, News and Information

Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis

Veröffentlicht am March 11, 2013 von Cristo Rey Intern

The authors present their experience related to the diagnosis, treatment, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis…

Getagged mit: autoantibodies, autoimmune, bullous dermatosis, bullous pemphigoid, IgA pemphigoid, pemphigoid, pemphigus, pemphigus vulgaris
Veröffentlicht unter Around the Globe, News and Information

Biochip Technology for the Serological Diagnosis of Bullous Pemphigoid

Veröffentlicht am February 20, 2013 von Cristo Rey Intern

Bullous pemphigoid is an autoimmune blistering skin disease characterized by the presence of circulating autoantibodies which recognize specific proteins of the epidermis and dermoepidermal junction. Diagnosis is based on clinical criteria and laboratory investigations, notably histology, direct and indirect immunofluorescence,…

Getagged mit: anti-BP180, anti-BP230, antigen, autoantibodies, biochip, bullous pemphigoid, ELISA
Veröffentlicht unter Around the Globe, News and Information, Technolgy

Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?

Veröffentlicht am February 5, 2013 von Cristo Rey Intern

Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the…

Getagged mit: autoantibodies, cross-reactivity, desmosomes, pemphigus, pemphigus erythematosus
Veröffentlicht unter Around the Globe, News and Information

Specific immunoglobulin isotypes correlate with disease activity, morphology, duration and HLA association in Pemphigus vulgaris.

Veröffentlicht am November 21, 2012 von Cristo Rey Intern

The molecular basis of disease heterogeneity in autoimmune conditions such as Pemphigus vulgaris is poorly understood. Although desmoglein 3 (Dsg3) has been well established as a primary target of immunoglobulin (Ig) autoantibodies in PV, there remain several questions regarding the…

Getagged mit: autoantibodies, desmoglein 3, HLA, IgG1, IgG4, immunoglobulin, isotype, pemphigus vulgaris
Veröffentlicht unter Around the Globe, News and Information

Therapeutic targets for pemphigus vulgaris discovered

Veröffentlicht am October 24, 2012 von Cristo Rey Intern

MedWire News: Researchers have identified the primary target of the autoantibodies found in the serum of patients with the blistering skin disorder pemphigus vulgaris (PV). PV patients develop antibodies against the proteins desmoglein (DSG)1 and 3, which help epidermal cells…

Getagged mit: autoantibodies, germline, pemphigus vulgaris, Somatic Mutation
Veröffentlicht unter Around the Globe, News and Information

Enrichment of total serum IgG4 in patients with pemphigus

Veröffentlicht am October 20, 2012 von Cristo Rey Intern

Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein (Dsg) adhesion proteins. Previous studies have shown an IgG4 > IgG1 predominance of anti-Dsg antibodies in pemphigus; however, no studies have examined total serum…

Getagged mit: autoantibodies, desmoglein, Dsg-specific antibodies, IgG4, pemphigus foliaceus, pemphigus vulgaris
Veröffentlicht unter Around the Globe, News and Information

Concurrence of bullous pemphigoid and herpetiform pemphigus with IgG antibodies to desmogleins 1/3 and desmocollins 1-3.

Veröffentlicht am October 12, 2012 von Cristo Rey Intern

MADAM, Autoantibodies in pemphigus target preferentially desmoglein 1 (Dsg1) and Dsg3, and rarely desmocollins 1-3 (Dsc1-3). Pemphigus herpetiformis (PH) is one of pemphigus subtypes and characterized by pruritic annular erythemas with vesicles in the periphery, rarity of mucosal involvement and…

Getagged mit: autoantibodies, bullous pemphigoid, pemphigus herpetiformis
Veröffentlicht unter Around the Globe, News and Information

Is there an emergent need to modify the Desmoglein compensation theory in pemphigus on the basis of ELISA data and alternative pathogenic mechanisms ?

Veröffentlicht am October 8, 2012 von Cristo Rey Intern

We read with interest the study by Koga H et al and we believe that in light of recent observations including our data the “desmoglein compensation theory” as a explanation for localization of blisters should be revisited. Although the disruption…

Getagged mit: autoantibodies, desmoglein, pemphigus, theory
Veröffentlicht unter Around the Globe, News and Information