Pemphigus can be a tough disease to live with but many patients now in remission have found inspiration, this is Sally’s story: I have been in remission now for over 1 year (YES!!!). That is complete remission with no symptoms…
Blog-Archive
Immunohistochemistry for immunoglobulin g4 on paraffin sections for the diagnosis of pemphigus.
Context.-Pemphigus is a group of autoimmune vesiculobullous diseases characterized by immunoglobulin G (IgG) antibodies directed against desmosomal adhesion proteins, with IgG4 being the predominant subclass in active diseases. Direct immunofluorescence for IgG performed on fresh-frozen tissue plays a crucial role…
Getagged mit: immunofluorescence, immunoglobulin G, pemphigus, pemphigus foliaceus, vesiculobullous disease
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Acantholytic rosacea of the forehead and scalp in a patient with Hailey-Hailey disease
BACKGROUND: Rosacea is a common dermatosis that can involve the bald area of the scalp. We report the case of a man presenting clinical symptoms of rosacea of the forehead and the scalp, but with a histological picture of familial…
Getagged mit: Acantholytic rosacea, Hailey-Hailey disease, immunofluorescence, Köbner phenomenon, pemphigus
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Pemphigus in Cats
Q. What is pemphigus? What is the best treatment? A. Pemphigus is a general term that describes four different disease entities, which we refer to as the Pemphigus Complex, primarily limited to the skin. All are considered to be immune mediated diseases.…
Getagged mit: cat, dermatology, pemphigus, veterinarian
Veröffentlicht unter Around the Globe, News and Information, Treatment and Medication
Veröffentlicht unter Around the Globe, News and Information, Treatment and Medication
Rituximab in pemphigus
Pemphigus is a chronic, muco-cutaneous autoimmune blistering disorder; two main variants being pemphigus vulgaris (PV) and pemphigus foliaceus (PF). PV is the most common subtype, varying between 75 to 92% of total pemphigus patients. Although no community based studies are undertaken…
Getagged mit: corticosteroid, DCP, IgG1, immunosuppressant, MabThera, pemphigus, pemphigus foliaceus, pemphigus vulgaris, rituxmab
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus
We evaluated the effectiveness of mizoribine, a newly developed immunosuppressive agent, as an adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. Eleven pemphigus patients (eight pemphigus vulgaris and three pemphigus foliaceus) received the combination therapy of…
Getagged mit: blood concentration level, corticosteroids, immunosuppressive agent, mizorbine, mizoribine, pemphigus, pemphigus foliaceus, prednisolone
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Is there an emergent need to modify the Desmoglein compensation theory in pemphigus on the basis of ELISA data and alternative pathogenic mechanisms ?
We read with interest the study by Koga H et al and we believe that in light of recent observations including our data the “desmoglein compensation theory” as a explanation for localization of blisters should be revisited. Although the disruption…
Getagged mit: autoantibodies, desmoglein, pemphigus, theory
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Efficacy of low-dose rituximab in a refractory acquired factor VIII inhibitor case secondary to pemphigus.
Acquired factor VIII (FVIII) inhibitor induces a bleeding disorder caused by specific antibodies to FVIII. The cause of approximately one fifth of cases can be attributed to autoimmune disorders, such as pemphigus. Here, we describe a case of refractory acquired…
Getagged mit: cyclosporine, FVIII, pemphigus, prednisolone, rituxmab
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Lack of relationship between blood groups and clinical outcome (body surface area affected) in patients with pemphigus vulgaris
Associations between blood groups and several diseases are observed in the literature. Some of these have scientific support suggesting a rationale, statistical relation. The association between ABO groups with several malignancies, hypercholesterolemia, thrombosis, myocardial infarction, duodenal ulcer, infections, and autoimmune…
Getagged mit: blood, pemphigus, pemphigus vulgaris, tests
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
Ultrastructure of acantholysis in pemphigus foliaceus reexamined from the current perspective.
Background Pemphigus foliaceus (PF) is a chronic cutaneous autoimmune blistering disease that is characterized by superficial blistering of the skin, and according to the current perspective is caused by autoantibodies directed against desmoglein 1 (Dsg1). Objectives To examine early acantholysis…
Getagged mit: desmosomes, pemphigus, pemphigus foliaceus
Veröffentlicht unter Around the Globe, News and Information
Veröffentlicht unter Around the Globe, News and Information
