Archivos Mensuales: October 2012

Ultrastructure of acantholysis in pemphigus foliaceus re-examined from the current perspective

Background  Pemphigus foliaceus (PF) is a chronic cutaneous autoimmune blistering disease that is characterized by superficial blistering of the skin, and according to the current perspective is caused by autoantibodies directed against desmoglein (Dsg) 1. Objectives  To examine early acantholysis

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Publicado en: Todo el mundo, Noticias e información

Therapeutic targets for pemphigus vulgaris discovered

MedWire News: Researchers have identified the primary target of the autoantibodies found in the serum of patients with the blistering skin disorder pemphigus vulgaris (PV). PV patients develop antibodies against the proteins desmoglein (DSG)1 and 3, which help epidermal cells

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Publicado en: Todo el mundo, Noticias e información

Corticosteroid-induced hyperglycemia is increased 10-fold in patients with pemphigus

This study aimed to highlight the importance of routine screening for hyperglycemia and to develop a standardized, evidence-based approach for the management of pemphigus patients on prolonged systemic corticosteroid (CS) therapy. A cross-sectional study was conducted in two university-affiliated teaching

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Publicado en: Todo el mundo, Noticias e información

Enrichment of total serum IgG4 in patients with pemphigus

Background  Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein (Dsg) adhesion proteins. Previous studies have shown an IgG4 > IgG1 predominance of anti-Dsg antibodies in pemphigus; however, no studies have examined total serum

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Publicado en: Todo el mundo, Noticias e información

Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients

Background  Promoter polymorphisms of the macrophage migration inhibitory factor gene are associated with increased production of macrophage migration inhibitory factor. Elevated levels of macrophage migration inhibitory factor have been observed in the sera of patients with pemphigus vulgaris. More than

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Publicado en: Todo el mundo, Noticias e información

Got a research question? Read this!

Patient-centric research is what it’s all about. Every time a pemphigus or pemphigoid patient helps with research, we all win. Tissue. Blood. Information. It is all equally important and every little bit helps.

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Publicado en: Todo el mundo, Investigación clínica, Noticias e información

Researchers Identify Immune System Targets Associated With Skin Blistering Disease Pemphigus Vulgaris

Pénfigo vulgar (PV) is an autoimmune disease in which the body’s immune system develops antibodies to two of its own proteins, the desmogleins DSG1 and DSG3 that help maintain the integrity of the skin. The immune attack causes painful blisters

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Publicado en: Todo el mundo, Noticias e información

Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus

We evaluated the effectiveness of mizoribine, a newly developed immunosuppressive agent, as an adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. Eleven pemphigus patients (eight pemphigus vulgaris and three pemphigus foliaceus) received the combination therapy of

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Publicado en: Todo el mundo, Noticias e información

Concurrence of bullous pemphigoid and herpetiform pemphigus with IgG antibodies to desmogleins 1/3 and desmocollins 1-3.

MADAM, Autoantibodies in pemphigus target preferentially desmoglein 1 (Dsg1) and Dsg3, and rarely desmocollins 1-3 (Dsc1-3). Pemphigus herpetiformis (PH) is one of pemphigus subtypes and characterized by pruritic annular erythemas with vesicles in the periphery, rarity of mucosal involvement and

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Publicado en: Todo el mundo, Noticias e información

Multiple cutaneous neutropenic ulcers associated with azathioprine

We report a case of neutropenic ulceration in a 42-year-old woman receiving azathioprine for pemphigus vulgaris. She developed multiple indolent ulcers involving the nose, neck, and back, after about 6-8 weeks following commencement of azathioprine 50 mg daily. The ulcers

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