Roche Holding AG (ROG)’s top-selling drug Rituxan effectively cured most cases of a rare and deadly skin disease in a patient study that suggests the medicine may replace steroids as the standard treatment. In a trial among 22 people with…
Klinik für Dermatologie, Allergologie und Venerologie, Universität Lübeck, Deutschland Klinik für Dermatologie und Allergologie, Philipps-Universität Marburg, Deutschland Klinik und Poliklinik für Dermatologie und Venerologie, Universität Köln, Deutschland Klinik für Dermatologie, Technische Universität Dresden, Deutschland Abteilung Rheumatologie, LMU München, Deutschland Abteilung…
OBJECTIVES: Hailey-Hailey disease (HHD), or benign familial pemphigus, is a rare autosomal dominant genodermatosis characterized by the formation of blisters. Eruptions are usually located in large skin folds, and when blisters become infected the condition can be very painful and disabling.…
Pénfigo vulgar (PV) is a life-threatening autoimmune blistering skin disease characterized by detachment of keratinocytes (acantholysis). It has been proposed that PV IgG might trigger signaling and that this process may lead to acantholysis. Indeed, we recently identified a rapid and dose-dependent phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and…
Background Hailey-Hailey disease (HHD) or familial benign chronic pemphigus is a rare autosomal dominant inherited skin disorder, characterized by flaccid vesicles and erosions on the intertriginous areas. Current treatments are not particularly effective. We report 6 cases dramatically improving with doxycycline.…
Q. What is pemphigus? What is the best treatment? A. Pemphigus is a general term that describes four different disease entities, which we refer to as the Pemphigus Complex, primarily limited to the skin. All are considered to be immune mediated diseases.…
A new study in mice where researchers replicated a rare type of immune cell in the lab and then infused it back into the body, is raising hope for a new treatment for severe autoimmune diseases such as multiple sclerosis…
Background - Glucocorticoids as sole therapy for pemphigus foliaceus (PF) in cats are not always successful, and it is common to need additional immunomodulating agents to manage the disease. Hypothesis/Objectives - This retrospective study evaluated the use of modified ciclosporin as an…
Managing Side Effects Radiation therapy Skin problems: Try not to scratch or rub the treated skin Chemotherapy Nausea and vomiting: Have small meals or snacks throughout the day instead of 2 or 3 large meals RITUXAN (a targeted therapy) Fever,…
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