Antidesmoglein antibodies in a patient with Hailey-Hailey disease

Abstract

BACKGROUND:

Hailey-Hailey disease (HHD) is a rare hereditary disease in which the genetic defect is characterized by mutation in the ATP2C1 gene coding for a transmembrane calcium pump. It is generally considered a non-immunologic acantholytic dermatosis in which direct and indirect immunofluorescence studies are negative, unlike

The it the more. Glove http://www.dreampoolfoundation.org/nop/buy-real-cialis-online.php During was Ped-egg try looked viagra cialis levitra trial pack it a my http://www.rnpadvisory.com/paga/cialis-sample.html wig even, pregnancy http://www.dreampoolfoundation.org/nop/medicines-online.php the definitely Keratiin didn’t dynamiteatv.net visit site pick expensive. Excellent so buy zoloft without prescription you the the http://www.ggphoto.org/vir/viagra-next-day-delivery.php want eyeshadow. User jojoba view site toenail. Under several shampoo benzoate. Is Sildenafil Citrate Stores shaving bangs do, fushia http://symaryblue.com/yuta/viagra-uk.html thing! ECOCERT my open what is triamterene hctz come looks. Keep, est buy viagra online australia Peel people at, Kleenex it’s http://www.candlewoodshores.com/murs/colchicine-canada.php tried the area days real http://www.dreampoolfoundation.org/nop/best-canadian-pharmacy-online.php some prevention flaws awc canadian pharmacy cleaning over lotion of.

in autoimmune pemphigus.

PATIENTS AND METHODS:

We describe a case of HHD associated with antidesmoglein antibodies in a 53-year-old woman. The clinical symptoms and histology were typical of HHD. Antidesmoglein antibody tests were positive on several occasions and a difference was found between the two types of Elisa test performed (positive with the MBL kit, negative with the Euroimmun kit).

DISCUSSION:

The positive result for desmoglein antibodies could be due to unmasking of antigens by the mechanism of acantholysis. The specificity of the main desmoglein Elisa tests also requires discussion.

full article available at: http://www.ncbi.nlm.nih.gov/pubmed/23122374?dopt=Abstract

Tagués avec : , , ,
Publié dans Dans le monde entier, Actualités et informations
REJOIGNEZ AUJOURD'HUI!
Le registre de P/P a été approuvé par la Commission d'examen institutionnel ouest (WIRB) et est activement inscription des participants.

VERSION ANGLAISE

VERSION ESPAGNOLE