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A Case of Pyodermatitis-Pyostomatitis Vegetans.

Pyodermatitis-pyostomatitis vegetans (PD-PSV) is a rare disorder characterized by mucocutaneous involvement and associated with inflammatory bowel disease. A 42-year-old woman with ulcerative colitis who manifested verrucous and pyogenic lesions on her scalp, neck, axillae, inguinal areas, umbilicus, trunk and oral

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Publié dans Dans le monde entier, Actualités et informations

Oral aphthosis: management gaps and recent advances.

Introduction: Though oral aphthosis is common, it has a significant impact on the quality of life in the patients. It is the most common oral ulcerative condition encountered in clinical practice. This study describes the characteristics and patterns of oral

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Publié dans Dans le monde entier, Actualités et informations

Oral pemphigus vegetans: A case report.

Pemphigus is a rare vesiculobullous autoimmune disease that exhibits blistering of the skin and oral cavity. It is caused by autoantibodies directed against antigens on the surface of keratinocytes. All forms of pemphigus are associated with the presence of circulating

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Publié dans Dans le monde entier, Actualités et informations

Immunohistochemistry for immunoglobulin g4 on paraffin sections for the diagnosis of pemphigus.

Context.-Pemphigus is a group of autoimmune vesiculobullous diseases characterized by immunoglobulin G (IgG) antibodies directed against desmosomal adhesion proteins, with IgG4 being the predominant subclass in active diseases. Direct immunofluorescence for IgG performed on fresh-frozen tissue plays a crucial role

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Publié dans Dans le monde entier, Actualités et informations

Acantholytic rosacea of the forehead and scalp in a patient with Hailey-Hailey disease

BACKGROUND: Rosacea is a common dermatosis that can involve the bald area of the scalp. We report the case of a man presenting clinical symptoms of rosacea of the forehead and the scalp, but with a histological picture of familial

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Publié dans Dans le monde entier, Actualités et informations

A case of stable oral pemphigus vulgaris on low dose immunosuppressive therapy

The clinical and epidemiological features of pemphigus vulgaris (PV) are well documented but there remain few reports of oesophageal involvement of PV. Although previously considered to be rare, recent reports have suggested that up to 87% of patients with PV

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Publié dans Dans le monde entier, Actualités et informations

Pemphigus foliaceus masquerading as IgA pemphigus and responding to dapsone

A 14-year-old male presented with seven years history of recurrent episodes of fluid filled, itchy and eroded lesions over the body not responding to oral corticosteroids and azathioprine. Dermatological examination revealed crusted plaques and erosions in a seborrheic distribution. Histopathology

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Publié dans Dans le monde entier, Actualités et informations

Findings around hair follicles and sweat glands in immunobullous disease

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Background Inherent to some immunobullous disorders is potential for intraepidermal or dermal–epidermal junction fragility, a phenomenon that may compromise biopsy specimen integrity and direct immunofluorescence (DIF) interpretation. In these situations, cutaneous adnexal structures (e.g. hair follicles, sweat apparatus) usually remain

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Publié dans Dans le monde entier, Actualités et informations

Clinical and immunological profile of umbilical involvement in pemphigus vulgaris and pemphigus foliaceus

Background.  Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune vesicobullous disorders with IgG autoantibodies directed against desmoglein (Dsg)1 and 3, which lead to intraepidermal acantholysis. Aim.  To characterize the clinical and immunological profile of patients with PF or PV with umbilical

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Publié dans Dans le monde entier, Essais cliniques, Actualités et informations

Analysis of High-dose Intravenous Immunoglobulin Therapy in Patients

High-dose intravenous immunoglobulin (IVIG) therapy is used in patients with severe autoimmune blistering diseases that are refractory to standard immunosuppressive therapy. To determine the efficacy and frequency of adverse events of IVIG therapy, we retrospectively analysed data for 16 patients

Publié dans Dans le monde entier, Actualités et informations

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