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A long–term study of a patient with anti-p200 pemphigoidcorrelation of autoantibody levels with disease activity and an example of epitope spreading

Anti-p200 pemphigoid is a rare subepidermal blistering disease associated with autoantibodies against a 200kDa protein, reportedly corresponding to laminin γ1. Cependant, direct evidence of the pathogenic potential of these antibodies is missing. We have followed up a patient with anti-p200

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Publié dans Dans le monde entier, Recherche clinique

Why Lesions Occur at Different Sites

By Grant J. Anhalt, M.D. Johns Hopkins Dermatology I will attempt to clarify what we know about the antibody response in various forms of pemphigus and how the distribution of the targeted antigens affects the location of lesions. The synthesis

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Publié dans Médical

Diagnostic Patterns and Delays in PV: Experience With 99 Patients

By David A. Sirois, D.M.D., Ph.D.Department of Oral Medicine Pemphigus vulgaris is a chronic autoimmune disease affecting the mucosa and skin and resulting in epithelial acantholysis, bullae formation, and chronic ulceration.1 Skin lesions of pemphigus vulgaris present clinically with typical

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Publié dans Médical

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