ארכיון שנתי: 2013

Targeting DSG3: from pemphigus to squamous cell carcinoma

Desmosomes are specialized structures of the cell membrane that are crucial for the establishment and maintenance of cell-cell adhesion and tissue integrity. Transmembrane proteins of desmosomes, desmogleins, and desmocollins are responsible for extracellular binding and, thus, are important for interkeratinocyte

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Paraneoplastic pemphigus: initial manifestation of lung cancer

Introduction The paraneoplastic pemphigus (PNP) is a neoplasia-associated autoimmune disease. It is characterized by a polymorphic mucocutaneous eruption, and its differential diagnoses are: pemphigus vulgaris, multiform erythema, Steven Johnson’s syndrome and lichen planus. It was first described in 1990. PNP

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Direct Immunofluorescence on Hair Follicles-Present and Future Perspectives.

Direct immunofluorescence (DIF) is an important tool for evaluating bullous autoimmune and connective tissue disorders.We report 21 cases of pemphigus vulgaris, bullous pemphigoid and lupus erythematosus that were investigated by performing DIF on scalp hair follicles. The study was done

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Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection

A 42-years old man was admitted to Peking Union Medical College Hospital because of blisters and mucosa erosions on both his lip and oral cavity for one month, he was diagnosed as “Behcet disease” and treated with cortisone. When cortisone

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Inflammation of the gingiva: The other reasons besides the obvious

Gingival inflammation is usually attributed to bacterial-induced gingivitis and/or periodontitis. Although bleeding is most often caused by this etiology, there can be other systemic issues at work. The most common of these entities are the diseases listed under the category

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Cicatricial pemphigoid

What is cicatricial pemphigoid? Cicatricial pemphigoid is an autoimmune disease that is characterised by blistering lesions on mucous membranes. It is also called benign mucous membrane pemphigoid or oral pemphigoid. Areas commonly involved are the oral mucosa (lining of the mouth) and conjunctiva

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Immunopathological characteristics of patients with bullous pemphigoid and neurological disease

The relationship between bullous pemphigoid (BP) and neurological disease has been the subject of numerous recent studies and BP antigens and their isoforms have been identified in the central nervous system (CNS). Whilst epidemiological data support this association, little is

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Roche’s Rituxan Cures Rare Skin-Blistering Disease in Study

Roche Holding AG (ROG)’s top-selling drug Rituxan effectively cured most cases of a rare and deadly skin disease in a patient study that suggests the medicine may replace steroids as the standard treatment. In a trial among 22 people with

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Effektivität und Sicherheit von Rituximab beim Pemphigus: Ergebnisse aus dem Deutschen Register für Autoimmunerkrankungen

Klinik für Dermatologie, Allergologie und Venerologie, Universität Lübeck, Deutschland  Klinik für Dermatologie und Allergologie, Philipps-Universität Marburg, Deutschland  Klinik und Poliklinik für Dermatologie und Venerologie, Universität Köln, Deutschland  Klinik für Dermatologie, Technische Universität Dresden, Deutschland  Abteilung Rheumatologie, LMU München, Deutschland  Abteilung

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Pemphigus Subaigu Malin à Bulles Extensives

Variété de pemphigus vulgaire se caractérisant par la présence de bulles qui finissent par confluer (se rejoindre) et se rompre, créant ainsi de vastes surfaces laissant la peau à vif qui suinte et qui devient très douloureuse. Généralités Le pemphigus

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