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Targeting DSG3: from pemphigus to squamous cell carcinoma

Desmosomes are specialized structures of the cell membrane that are crucial for the establishment and maintenance of cell-cell adhesion and tissue integrity. Transmembrane proteins of desmosomes, desmogleins, and desmocollins are responsible for extracellular binding and, thus, are important for interkeratinocyte

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Specific immunoglobulin isotypes correlate with disease activity, morphology, duration and HLA association in Pemphigus vulgaris.

The molecular basis of disease heterogeneity in autoimmune conditions such as Pemphigus vulgaris is poorly understood. Although desmoglein 3 (Dsg3) has been well established as a primary target of immunoglobulin (Ig) autoantibodies in PV, there remain several questions regarding the

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The P/P Registry has been approved by the Western Institutional Review Board (WIRB) and is actively enrolling participants.

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