Pemphigus is a rare vesiculobullous autoimmune disease that exhibits blistering of the skin and oral cavity. It is caused by autoantibodies directed against antigens on the surface of keratinocytes. All forms of pemphigus are associated with the presence of circulating…
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Oral pemphigus vegetans: A case report.
Taggato con: immunofluorescence, mucosal plaques, pemphigus vegetans, pemphigus vulgaris
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
A case of stable oral pemphigus vulgaris on low dose immunosuppressive therapy
The clinical and epidemiological features of pemphigus vulgaris (PV) are well documented but there remain few reports of oesophageal involvement of PV. Although previously considered to be rare, recent reports have suggested that up to 87% of patients with PV…
Taggato con: azathioprine, immunosuppression, mucocutaneous, oesophageal lesions, OESOPHAGUS, pemphigus vulgaris, prednisolone, UPPER GASTROINTESTINAL SYMPTOMS
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Clinical and immunological profile of umbilical involvement in pemphigus vulgaris and pemphigus foliaceus
Background. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune vesicobullous disorders with IgG autoantibodies directed against desmoglein (Dsg)1 and 3, which lead to intraepidermal acantholysis. Aim. To characterize the clinical and immunological profile of patients with PF or PV with umbilical…
Taggato con: desmoglein, Erythema, pemphigus foliaceus, pemphigus vulgaris
Pubblicato in Around the Globe, Sperimentazioni cliniche, News and Information
Pubblicato in Around the Globe, Sperimentazioni cliniche, News and Information
Specific immunoglobulin isotypes correlate with disease activity, morphology, duration and HLA association in Pemphigus vulgaris.
The molecular basis of disease heterogeneity in autoimmune conditions such as Pemphigus vulgaris is poorly understood. Although desmoglein 3 (Dsg3) has been well established as a primary target of immunoglobulin (Ig) autoantibodies in PV, there remain several questions regarding the…
Taggato con: autoantibodies, desmoglein 3, HLA, IgG1, IgG4, immunoglobulin, isotype, pemphigus vulgaris
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Rituximab in pemphigus
Pemphigus is a chronic, muco-cutaneous autoimmune blistering disorder; two main variants being pemphigus vulgaris (PV) and pemphigus foliaceus (PF). PV is the most common subtype, varying between 75 to 92% of total pemphigus patients. Although no community based studies are undertaken…
Taggato con: corticosteroid, DCP, IgG1, immunosuppressant, MabThera, pemphigus, pemphigus foliaceus, pemphigus vulgaris, rituxmab
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Randomized double blind trial of prednisolone and azathioprine
Background The classic treatment for pemphigus vulgaris is prednisolone. Immunosuppressive drugs can be used in association. Objective To compare the efficacy of Azathioprine in reducing the Disease Activity Index (DAI). Patients and methods A double blind randomized controlled study was conducted on 56…
Taggato con: azathioprine, DAI, immunosuppressant, pemphigus vulgaris, placebo, prednisolone, thiopurine methyltransferase
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Therapeutic targets for pemphigus vulgaris discovered
MedWire News: Researchers have identified the primary target of the autoantibodies found in the serum of patients with the blistering skin disorder pemphigus vulgaris (PV). PV patients develop antibodies against the proteins desmoglein (DSG)1 and 3, which help epidermal cells…
Taggato con: autoantibodies, germline, pemphigus vulgaris, Somatic Mutation
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Corticosteroid-induced hyperglycemia is increased 10-fold in patients with pemphigus
This study aimed to highlight the importance of routine screening for hyperglycemia and to develop a standardized, evidence-based approach for the management of pemphigus patients on prolonged systemic corticosteroid (CS) therapy. A cross-sectional study was conducted in two university-affiliated teaching…
Taggato con: hyperglycemia, mucous membrane pemphigoid, pemphigus foliaceus, pemphigus vulgaris, Screening
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Enrichment of total serum IgG4 in patients with pemphigus
Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein (Dsg) adhesion proteins. Previous studies have shown an IgG4 > IgG1 predominance of anti-Dsg antibodies in pemphigus; however, no studies have examined total serum…
Taggato con: autoantibodies, desmoglein, Dsg-specific antibodies, IgG4, pemphigus foliaceus, pemphigus vulgaris
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients
Background Promoter polymorphisms of the macrophage migration inhibitory factor gene are associated with increased production of macrophage migration inhibitory factor. Elevated levels of macrophage migration inhibitory factor have been observed in the sera of patients with pemphigus vulgaris. More than…
Taggato con: genotype, pemphigus vulgaris, polymorphism, study
Pubblicato in Around the Globe, News and Information
Pubblicato in Around the Globe, News and Information
