Bullous pemphigoid (BP) represents the most common autoimmune subepidermal blistering disease. BP typically affects the elderly and is associated with significant morbidity. It has usually a chronic course with spontaneous exacerbations. The cutaneous manifestations of BP can be extremely protean.…
月別アーカイブ: May 2012
Pemphigus vulgaris treated with adalimumab: case study
ABSTRACT The study describes the case of a patient with a clinical and histopathological diagnosis of pemphigus vulgaris accompanied by severe side‐effects of combined immunosuppressive therapy, who achieved a remission of the disease with adalimumab. Pemphigus vulgaris is a chronic…
Mycophenolate Mofetil for the Management of Autoimmune Bullous Diseases
This article reviews the use of MMF for the treatment of several bullous conditions, and assesses the evidence gathered from clinical trials and case series. According to numerous case series, MMF could be of value in treating refractory disease.…
Pathogenesis of Bullous Pemphigoid
Bullous pemphigoid, the most common autoimmune blistering disease, is induced by autoantibodies against type XVII collagen. Passive transfer of IgG or IgE antibodies against type XVII collagen into animals has revealed not only the pathogenicity of these antibodies but also…
Evidence for vitamin D deficiency and increased fractures’ prevalence in autoimmune bullous skin diseases.
Conclusions The low 25OHD levels found in PV and BP may suggest a role for this agent in their pathogenesis. The increased prevalence of fractures should be taken into consideration in patients who must be given corticosteroid. (Source: British Journal…
Diagnosis and Clinical Features of Pemphigus Vulgaris
Autoimmune bullous diseases are associated with autoimmunity against structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include those where the skin blisters at the basement membrane zone and those where the skin…
Azathioprine in the treatment of Autoimmune Blistering diseases
Although there are no standard guidelines for the treatment of autoimmune blistering diseases, azathioprine has shown good efficacy in acquired autoimmune blistering diseases, and is well tolerated. Side effects of azathioprine normally occur in mild variants. Severe reactions are due…
