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Paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome.

Paraneoplastic pemphigus is the term used for an exclusive subset of pemphigus.

The clinical lesions may resemble pemphigus, pemphigoid, erythema multiforme, graft-vs.-host disease, or lichen planus. A common denominator in all patients is the concomitant occurrence of either occult or confirmed systemic neoplasm. It is imperative to confirm the diagnosis through microscopy, where intraepidermal suprabasal cleavage, epidermal acantholysis, dyskeratotic keratinocytes and vacuolar

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changes in the basal epidermis, interfacial dermatitis, and epidermal exocytosis can be seen. Furthermore, the deposition of immunoglobulin G (IgG) and complement in the epidermal intercellular spaces, detected by direct and/or indirect immunofluorescence, is equally crucial for confirming the diagnosis.


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Paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome.” への1件のコメント
  1. LaRaine m. Hummel says:

    I do wish you had more on BP.

  2. We are working on that. In the meantime, you can search our Resource Center where I found this document:


The P/P Registry has been approved by the Western Institutional Review Board (WIRB) and is actively enrolling participants.