A 14-year-old male presented with seven years history of recurrent episodes of fluid filled, itchy and eroded lesions over the body not responding to oral corticosteroids and azathioprine. Dermatological examination revealed crusted plaques and erosions in a seborrheic distribution. Histopathology…
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Acantholysis revisited: Back to basics
Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders. Although a well-known concept, 는…
Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis
The authors present their experience related to the diagnosis, 치료, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis…
Paraneoplastic Pemphigus: A Paraneoplastic Autoimmune Multiorgan Syndrome or Autoimmune Multiorganopathy?
Paraneoplastic pemphigus (PNP), a clinically and immunopathologically distinct mucocutaneous blistering dermatosis, is a severe form of autoimmune multiorgan syndrome generally associated with poor therapeutic outcome and high mortality. This IgG-mediated disease is initiated by an obvious or occult lymphoproliferative disorder…
Localized pemphigus with vegetative features
We present a 58-year-old Jamaican man with an eight-month history of an isolated, vegetative, eroded, and crusted plaque on the posterior aspect of the scalp. One month prior to referral to the Charles C. Harris Skin and Cancer Pavilion he…
태그됨： IgG, Jamaica, localized pemphigus, pemphigus, pemphigus vulgaris, vegetative
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전세계, 뉴스 및 정보 에 올린 글
Biochip Technology for the Serological Diagnosis of Bullous Pemphigoid
Bullous pemphigoid is an autoimmune blistering skin disease characterized by the presence of circulating autoantibodies which recognize specific proteins of the epidermis and dermoepidermal junction. Diagnosis is based on clinical criteria and laboratory investigations, notably histology, direct and indirect immunofluorescence,…
태그됨： anti-BP180, anti-BP230, antigen, autoantibodies, biochip, bullous pemphigoid, 엘리 사
전세계, 뉴스 및 정보, Technolgy 에 올린 글
전세계, 뉴스 및 정보, Technolgy 에 올린 글
Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris
There are a limited number of reports indicating the role of human leukocyte antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty…
태그됨： class I alleles, haplotype, human leukocyte antigen, Iranian patients, pemphigus vulgaris
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전세계, 뉴스 및 정보 에 올린 글
Pemphigus and Pemphigoid in Domestic Animals: An Overview
Pemphigus and pemphigoid are uncommon dermatological entities in domestic animals and of a presumed autoimmune nature. In one form or another, they have been reported in the dog, cat, horse and goat. Although these diseases are considered to be…
Equine Pemphigus Foliaceus
Pemphigus foliaceus (pem-fi-gus foli-a-shus) is an auto immune disease that affects humans and dogs and, to a lesser extent, cats and horses. In horses, it is characterized by primary lesions that often begin on the head and lower extremities; secondary…
Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the…
태그됨： autoantibodies, cross-reactivity, desmosomes, pemphigus, pemphigus erythematosus
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전세계, 뉴스 및 정보 에 올린 글
