OBJECTIVES: Hailey-Hailey disease (HHD), or benign familial pemphigus, is a rare autosomal dominant genodermatosis characterized by the formation of blisters. Eruptions are usually located in large skin folds, and when blisters become infected the condition can be very painful and disabling.…
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p38MAPK inhibition prevents disease in pemphigus vulgaris mice.
Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease characterized by detachment of keratinocytes (acantholysis). It has been proposed that PV IgG might trigger signaling and that this process may lead to acantholysis. Indeed, we recently identified a rapid and dose-dependent phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and…
Familial benign chronic pemphigus and doxycycline
Background Hailey-Hailey disease (HHD) or familial benign chronic pemphigus is a rare autosomal dominant inherited skin disorder, characterized by flaccid vesicles and erosions on the intertriginous areas. Current treatments are not particularly effective. We report 6 cases dramatically improving with doxycycline.…
Pemphigus in Cats
Q. What is pemphigus? What is the best treatment? A. Pemphigus is a general term that describes four different disease entities, which we refer to as the Pemphigus Complex, primarily limited to the skin. All are considered to be immune mediated diseases.…
Hope For New Autoimmune Disease Treatment Using Rare Immune Cells
A new study in mice where researchers replicated a rare type of immune cell in the lab and then infused it back into the body, is raising hope for a new treatment for severe autoimmune diseases such as multiple sclerosis…
Use of modified ciclosporin in the management of feline pemphigus foliaceus: a retrospective analysis.
Background - Glucocorticoids as sole therapy for pemphigus foliaceus (PF) in cats are not always successful, and it is common to need additional immunomodulating agents to manage the disease. Hypothesis/Objectives - This retrospective study evaluated the use of modified ciclosporin as an…
Important Safety Information
Managing Side Effects Radiation therapy Skin problems: Try not to scratch or rub the treated skin Chemotherapy Nausea and vomiting: Have small meals or snacks throughout the day instead of 2 or 3 large meals RITUXAN (a targeted therapy) Fever,…
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Comparative effectiveness research should inform decision making
Are patients swimming in a sea of health information? Or are they drowning in it?
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Treatment of Ocular Mucous Membrane Pemphigoid with Immunosuppressive Drug Therapy
Jennifer E. Thorne, MD, PhD(1,2)Fasika A. Woreta, MD, MPH(1)Douglas A. Jabs, MD, MBA(1,2,3)Grant J. Anhalt, MD(4) Received 5 March 2008; received in revised form 3 June 2008; accepted 1 August 2008. published online 20 October 2008 Purpose To evaluate the…
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Is there anything I can do to reduce the price of medication?
The costs of medication are high and many people have trouble paying for them if they don’t have medical insurance. You need to take your medication exactly as your doctor wants you to. Skipping doses or reducing doses on your…
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