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Early diagnosis may permit successful treatment with only low levels of medication. Consult a dermatologist if there are any persistent skin or mouth lesions. Because they are so rare, pemphigus and pemphigoid are often the last disease considered during diagnosis.

For a definite diagnosis, doctors should consider:

  • Clinical presentation — visual examination of skin lesions.
  • Lesion biopsy — A sample of the blistered skin is removed and examined under the microscope. Additionally, the layer of skin in which cell-to-cell separation occurs can be determined.
  • Direct immunoflourescence — The skin sample is treated to detect desmoglein antibodies in the skin. The presence of these antibodies indicates pemphigus.
  • Indirect Immunofluorescence or antibody titer test. This measures desmoglein autoantibodies in the blood serum. 질병의 과정을 더 완벽 하 게 이해를 얻기 위해 사용할 수 있습니다..
  • 엘리 사 Desmoglein 항 체에 대 한 혈 청 분석 결과, 엘리 사로 알려진, 사용할 수 있습니다.. 많은 경우에는 엘리 사 병과 활동 사이의 상관 관계 하지만 모든 경우에 너무.

제발 그 immunoflourescent 테스트 note (항 체를 순환 하는 것에 대 한 테스트) MMP 매우 안정적 이며 대부분의 경우에서 음수에 대 한. 그것은 긍정적인 직접 immunoflourescence 결과 얻기 위해 중요 한 (biopsies), 이끼 planus와 같은 다른 질병을 모방 수 있기 때문에 반복 biopsies을 요구 하는 경우에.

입과 코에만 참여 경우, 치료는 국 소 스테로이드에 국한 되어야 합니다., intralesional 스테로이드 주사, 또는 경구 코르 티 코 스테로이드의 짧은 버스트를 가끔.

경우에 참여 하는 잇 몸, topical therapy applied with flexible dental trays (similar to the disposable molds used to deliver fluoride treatments to the teeth).

A different situation exists if the eyes, esophagus or larynx are involved. In such cases, involvement could include blindness and asphyxiation (due to scarring), and aggressive systemic therapy is warranted. Systemic steroids may not adequately control progression; most other therapies only slow the scarring process. The treatment of choice is oral cyclophosphamide (Cytoxan). About 3/4 of the patients treated with this regimen tolerate the drug. Most of these patients will have complete clinical remission after all drugs are withdrawn.

Occasionally, patients respond to oral dapsone. Those that respond well do so quickly, but unfortunately, these patients are in the minority. Azathioprine and Mycophenolate Mofetil is an alternative for patients who cannot tolerate Cytoxan. Cyclosporine is not recommended for use in MMP/CP. Recently, the biologics have been noted as being an alternative treatment for MMP/CPspecifically rituximab, etanercept, and infliximab.