Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease presenting clinically with blisters or erosions of the skin and mucous membrane. The main histopathologic characteristic of this disease is suprabasal vesicles due to loss of cell–cell adhesion between keratinocytes named acantholysis.…
Meeting of interest
A small, but perfectly formed group of PEM Friends braved the floods in the UK on Monday 26th November 2012 to have a sociable lunch together and share their experiences of Pemphigus and Pemphigoid. Even though it was a low turnout…
Inspiration and hope for pemphigus
Pemphigus can be a tough disease to live with but many patients now in remission have found inspiration, this is Sally’s story: I have been in remission now for over 1 year (YES!!!). That is complete remission with no symptoms…
Paraneoplastic pemphigus associated with dendritic cell neoplasm and Castleman’s disease: report of a new case and review of the literature
We report on a patient with longstanding multicentric Castleman’s disease, hyaline-vascular type, who developed a follicular dendritic cell sarcoma, and finally presented a fatal paraneoplastic pemphigus. We review all four cases of such a triple association described in the…
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Prison Dermatology
Experience in the Texas Department of Criminal Justice Dermatology Clinic In this article, the authors review the skin conditions seen in a dermatology referral clinic for inmates in the Texas Department of Criminal Justice system at the University of Texas…
A Case of Pyodermatitis-Pyostomatitis Vegetans.
Pyodermatitis-pyostomatitis vegetans (PD-PSV) is a rare disorder characterized by mucocutaneous involvement and associated with inflammatory bowel disease. A 42-year-old woman with ulcerative colitis who manifested verrucous and pyogenic lesions on her scalp, neck, axillae, inguinal areas, umbilicus, trunk and oral…
Oral aphthosis: management gaps and recent advances.
Introduction: Though oral aphthosis is common, it has a significant impact on the quality of life in the patients. It is the most common oral ulcerative condition encountered in clinical practice. This study describes the characteristics and patterns of oral…
Oral pemphigus vegetans: A case report.
Pemphigus is a rare vesiculobullous autoimmune disease that exhibits blistering of the skin and oral cavity. It is caused by autoantibodies directed against antigens on the surface of keratinocytes. All forms of pemphigus are associated with the presence of circulating…
태그됨： immunofluorescence, mucosal plaques, pemphigus vegetans, pemphigus vulgaris
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Immunohistochemistry for immunoglobulin g4 on paraffin sections for the diagnosis of pemphigus.
Context.-Pemphigus is a group of autoimmune vesiculobullous diseases characterized by immunoglobulin G (IgG) antibodies directed against desmosomal adhesion proteins, with IgG4 being the predominant subclass in active diseases. Direct immunofluorescence for IgG performed on fresh-frozen tissue plays a crucial role…
Antidesmoglein antibodies in a patient with Hailey-Hailey disease
Abstract BACKGROUND: Hailey-Hailey disease (HHD) is a rare hereditary disease in which the genetic defect is characterized by mutation in the ATP2C1 gene coding for a transmembrane calcium pump. It is generally considered a non-immunologic acantholytic dermatosis in which direct…
