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Risk Fact-ors | International Pemphigus Pemphigoid Foundation

Risk Fact-ors

The following riskfact”-ors are provided to clarify misconceptions about pemphigus and pemphigoid.

Pemphigus

  • Activities: none established as a risk
  • Pesticides: none known
  • Malignancy: For paraneoplastic pemphigus only: seen in patients with concurrent neoplasia, most often: non-Hodgkins Lymphoma, Chronic Lymphocytic Leukemia, and Castleman’s disease (m). Others include adenocarcinoma (pancreas and colon most common; also breast, prostate); hepatocellular carcinoma, squamous cell carcinoma, thymoma, Waldenstroms macoglobulinemia and others.
  • Drugs (see Table below)
  • Infection: unknown / not reported
  • Foods: no known foods are causally related.
    • 아무도 이러한 식품을 피해 야 한다, 그러나 배려는 개별적으로 주어질 수 있다, 일부 환자 보고 특정 식품 그룹 4 개의 성분 중 하나 이상을 포함 하 여 질병의 격화: thiol, isothiocyanates, 페 놀 또는 tannins.
    • Thiols: 부추속의 다른 구성원과 마늘 양파와 같은 식물을 포함 하는 그룹, 샬 롯, 부추 및 골 파.
    • Isothiocyanates (겨자 기름): 발견 3200 겨자를 포함 한 식물의 종, 고추 냉이, 겨울 유채과 야채, 순 무, 브로콜리, 무, 양배추, brussel 콩나물과 콜리플라워. 케이 퍼. 겨자 합성 오일.
    • 페 놀: Urushiol 접촉 피부염을 일으킬 수 있고 가장 주목할 만한에 포이즌 아이비, 옻과 망고과 관련 있는 독이 옻나무, 피스타치오와 캐슈. 인공 감미료 아스파탐은 페 놀과 공통점이 많은 식품 첨가물. 페 놀 계 및 cinnamic 산에, 그리고 pinene. 그것은 토마토에, 감자, 망고 및 바나나와 우유와 우유 제품 때 소 소비 페 놀 생산 엮 여 먹이 면 실 등.
    • Tannins: 탄 닌의 일반적인 소스는 콜라 너트, 차, 커피, 라즈베리, 체리, 적갈색, 블랙베리, 아보카도, 바나나, 애플, 망고, 배, 가지와 포도 스킨, 커피와 코코아 씨앗, 생강, 인삼, 마늘, 로즈마리, 칡,.
  • Stress: no known relationship. 그러나, many patients report that stress (physical, physiological and psychological) exacerbates the disease.

 

Table 3:  Drugs associated with these conditions
Drugs associated with pemphigus vulgaris (n) Drugs associated with drug-induced bullous pemphigoid (n)
Captopril *, Enalapril, Cilazapril, Ramipril Ampicillin
Cephalosporins – cefadoxil and cephamandole, ceftazidime, ceftriaxone, cefuroxime, cephalexin Captopril*, Enalapril
Gold sodium thiomalate * Chloroquine
Interleukin Furosemide
Levodopa Penicillamine*
NSAIDs Penicillinsamoxil, ampicillin, penicillin, benyzylpenicllin
Penicillamine * Sulfapyridine
Penicillins – amoxil, ampicillin, pencillin, benyzylpenicllin Sulfasalazine
Phenobarbital PUVA: Psoralen with Ultraviolet A
Piroxicam  
Propranolol  
Pyritinol *  
Quinolones – nalidixic acid, lomafloxacin  
Rifamycinsrifampin  
Thioprine *  

*sulfur containing

Pemphigoid

  • Age: increasing incidence with age.
  • Correlations between BP flare in disease activity and recurrence of underlying cancer suggest such an association in individual patients.

Myth and Lore

Myths associated with pemphigus and MMP

  • “they are old person’s diseases.” Mean age for PV is 40-60, for MMP is 40+.
  • “whether you receive treatment or not, these diseases are fatal.” (wrong)
  • “enhancing the immune system will cure pemphigus”(wrong)
  • “pemphigus and pemphigoid are curable diseases” (wrong – but long term remissions are seen; see later)
  • “alternative medicines will cure pemphigus” (not demonstrated)

 

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