Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders. Although a well-known concept, 는…
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A Possible Use of Cholinergic Drugs in Pemphigus Vulgaris
Human epidermis shows a non-neuronal cholinergic system including keratinocyte (kc) acetylcholine (Ach) axis which is composed by enzymes and two families of Ach receptors (muscarinic and nicotinic receptors). The activity of these two receptors can regulate the interkeratinocytes and kcs-extracellular…
Antidesmoglein antibodies in a patient with Hailey-Hailey disease
Abstract BACKGROUND: Hailey-Hailey disease (HHD) is a rare hereditary disease in which the genetic defect is characterized by mutation in the ATP2C1 gene coding for a transmembrane calcium pump. It is generally considered a non-immunologic acantholytic dermatosis in which direct…
Ultrastructure of acantholysis in pemphigus foliaceus reexamined from the current perspective
Background Pemphigus foliaceus (PF) is a chronic cutaneous autoimmune blistering disease that is characterized by superficial blistering of the skin, and according to the current perspective is caused by autoantibodies directed against desmoglein 1 (Dsg1). Objectives To examine early acantholysis…
Pemphigus in China
By Dr. Pan Meng Pemphigus is a group of organ-specific autoimmune disorders, including pemphigus vulgaris (PV), pemphigus foliaceus (PF) and paraneoplastic pemphigus (PNP). PV is the most common disease and represents this kind of potentially life-threatening disease. It is characterized…
Why Lesions Occur at Different Sites
By Grant J. Anhalt, M.D. Johns Hopkins Dermatology I will attempt to clarify what we know about the antibody response in various forms of pemphigus and how the distribution of the targeted antigens affects the location of lesions. The synthesis…
태그됨： acantholysis, autoantibodies, autoantibody, autoimmunity, dermatology, keratinocyte, manipulation, mucocutaneous, paraneoplastic
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