Background Adjuvant therapeutic methods are employed when pemphigus vulgaris (PV) fails to be controlled by conventional corticosteroid treatment. Objective: The efficacy of double filtration plasmapheresis (DFPP) was investigated in a PV patient with severe, refractory mucosal disease. Methods A total…
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Desmosomal adhesion and pemphigus vulgaris: the first half of the story
Pemphigus vulgaris (PV) is a paradigm of autoimmune disease affecting intercellular adhesion. The mechanisms that lead to cell–cell detachment (acantholysis) have crucial therapeutic implications and are currently undergoing major scrutiny. The first part of this review focuses on the classical…
Oxidative stress and autoimmune skin disease.
Antioxidants play the important role in our body of neutralizing free radicals and peroxides that are formed during normal physiologic events. While these reactive oxygen species are necessary for numerous biological processes, when created in excess they can have deleterious…
태그됨： alopecia areata, Oxidative stress, pemphigus, pemphigus vulgaris, psoriasis, vitiligo
전세계, 뉴스 및 정보 에 올린 글
전세계, 뉴스 및 정보 에 올린 글
Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis
The authors present their experience related to the diagnosis, 치료, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis…
Localized pemphigus with vegetative features
We present a 58-year-old Jamaican man with an eight-month history of an isolated, vegetative, eroded, and crusted plaque on the posterior aspect of the scalp. One month prior to referral to the Charles C. Harris Skin and Cancer Pavilion he…
태그됨： IgG, Jamaica, localized pemphigus, pemphigus, pemphigus vulgaris, vegetative
전세계, 뉴스 및 정보 에 올린 글
전세계, 뉴스 및 정보 에 올린 글
Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris
There are a limited number of reports indicating the role of human leukocyte antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty…
태그됨： class I alleles, haplotype, human leukocyte antigen, Iranian patients, pemphigus vulgaris
전세계, 뉴스 및 정보 에 올린 글
전세계, 뉴스 및 정보 에 올린 글
p38MAPK inhibition prevents disease in pemphigus vulgaris mice.
Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease characterized by detachment of keratinocytes (acantholysis). It has been proposed that PV IgG might trigger signaling and that this process may lead to acantholysis. Indeed, we recently identified a rapid and dose-dependent phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and…
A Possible Use of Cholinergic Drugs in Pemphigus Vulgaris
Human epidermis shows a non-neuronal cholinergic system including keratinocyte (kc) acetylcholine (Ach) axis which is composed by enzymes and two families of Ach receptors (muscarinic and nicotinic receptors). The activity of these two receptors can regulate the interkeratinocytes and kcs-extracellular…
Study of apoptosis in oral pemphigus vulgaris
Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease presenting clinically with blisters or erosions of the skin and mucous membrane. The main histopathologic characteristic of this disease is suprabasal vesicles due to loss of cell–cell adhesion between keratinocytes named acantholysis.…
Oral aphthosis: management gaps and recent advances.
Introduction: Though oral aphthosis is common, it has a significant impact on the quality of life in the patients. It is the most common oral ulcerative condition encountered in clinical practice. This study describes the characteristics and patterns of oral…
