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Researchers Identify Immune System Targets Associated With Skin Blistering Disease Pemphigus Vulgaris

Pemphigus vulgaris (PV) is an autoimmune disease in which the body’s immune system develops antibodies to two of its own proteins, the desmogleins DSG1 and DSG3 that help maintain the integrity of the skin. The immune attack causes painful blisters

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Geplaatst in Around the Globe, News and Information

Multiple cutaneous neutropenic ulcers associated with azathioprine

We report a case of neutropenic ulceration in a 42-year-old woman receiving azathioprine for pemphigus vulgaris. She developed multiple indolent ulcers involving the nose, neck, and back, after about 6-8 weeks following commencement of azathioprine 50 mg daily. The ulcers

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Geplaatst in Around the Globe, News and Information

Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome

Introduction: Myasthenia gravisis an autoimmune disease marked by neuromuscular transmission failure at the neuromuscular junction. Castleman disease is a rare lymphoproliferative disease characterized by non-cancerous angiofolicular hyperplasia of lymphatic tissue. Methods and results: We describe a young man with rapid,

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Geplaatst in Around the Globe, News and Information

Twins with Neonatal Pemphigus Vulgaris Born to a Mother with Pemphigus Vulgaris: A Case Report

Dichorionic diamniotic twins were born at 37 weeks of gestation by cesarean section to a 34-year-old primigravid Japanese woman because the first twin was in breech presentation. The mother had been diagnosed with pemphigus vulgaris prior to her pregnancy. In addition

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Geplaatst in Around the Globe, News and Information

Lack of relationship between blood groups and clinical outcome (body surface area affected) in patients with pemphigus vulgaris

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Associations between blood groups and several diseases are observed in the literature. Some of these have scientific support suggesting a rationale, statistical relation. The association between ABO groups with several malignancies, hypercholesterolemia, thrombosis, myocardial infarction, duodenal ulcer, infections, and autoimmune

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Study of oral, ear, nose and throat involvement in pemphigus vulgaris by endoscopic examination.

Background:  Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. There are two different clinical forms: mucocutaneous (MCPV) or mucosal (MPV). However, it is not clear how PV

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Geplaatst in Around the Globe, News and Information

Association between HLA-DRB1 polymorphisms and pemphigus vulgaris: a meta-analysis

Background  Several studies have reported that HLA-DRB1 may be correlated with pemphigus vulgaris (PV), but most have been based on small samples and the results remain inconsistent and unclear. Objectives  To investigate the correlation between DRB1 and PV by a

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Enrichment of total serum IgG4 in pemphigus patients

Background:  Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein adhesion proteins. Previous studies have shown an IgG4>IgG1 predominance of anti-desmoglein antibodies in pemphigus; however, no studies have examined total serum IgG4

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Geplaatst in Around the Globe, News and Information

Pediatric Pemphigus Vulgaris: Durable Treatment Responses Achieved with Prednisone and Mycophenolate Mofetil (MMF)

This report describes the clinical presentations and treatment responses of three children with PV, as confirmed according to histology and indirect immunofluorescence studies. In all three cases, oral prednisone used in conjunction with mycophenolate mofetil (MMF) resulted in complete clinical

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Letter: Acetylcholine receptor antibodies in patients with pemphigus vulgaris: Correlation with disease extent at the time of diagnosis and during follow-up.

Several studies have tried to determine the relationship between auto-antibodies against the acetylcholine receptor and the development of pemphigus vulgaris. In this study, we observed that antibody levels against the acetylcholine receptor are mildly elevated in pemphigus vulgaris (PV), and

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