Antioxidants play the important role in our body of neutralizing free radicals and peroxides that are formed during normal physiologic events. While these reactive oxygen species are necessary for numerous biological processes, when created in excess they can have deleterious…
Archiwum Bloga
Oxidative stress and autoimmune skin disease.
Tagi: alopecia areata, Oxidative stress, pemphigus, pemphigus vulgaris, psoriasis, vitiligo
Napisano w Around the Globe, News and Information
Napisano w Around the Globe, News and Information
Application for Tacrolimus Ointment in Treating Refractory Inflammatory Ocular Surface Diseases
Purpose To evaluate the therapeutic effects of topical tacrolimus ointment on refractory inflammatory ocular surface diseases. Design Retrospective interventional consecutive case series. Methods In Severance Hospital, Seoul, South Korea, 0.02% tacrolimus ointment was topically applied 1 do 3 times per…
An attempt to develop mouse model for anti-laminin γ1 pemphigoid.
BACKGROUND: We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. Jednakże, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding…
Lobar torsion after lung transplantation
Lobar torsion is a rare complication after lung transplantation. Here we report a case of right middle lobe (RML) torsion after bilateral sequential lung transplantation (BLTx). This 30-year-old lady underwent BLTx for bronchiolitis obliterans due to paraneoplastic pemphigus. The right…
Drug-triggered pemphigus foliaceus
Pemphigus foliaceus (PF) is the most common autoimmune skin disease of dogs and other animal species. Although PF can spontaneously affect dogs of any breed, it appears more prevalent in Akita Inus and chow chows in the United States. The…
Endemic pemphigus in the peruvian Amazon: epidemiology and risk factors for the development of complications during treatment
BACKGROUND: Pemphigus is an autoimmune blistering disease. According to a report, in areas of endemic pemphigus foliaceus (EPF) in Peru there are cases of pemphigus vulgaris with epidemiologic, clinical and histopathologic characteristics similar to those of “endemic pemphigus vulgaris” (EPV) in…
Metformin in dermatology: an overview.
For several decades, metformin has been used as an oral hypoglycaemic agent, where it is the first line of treatment in overweight and obese type 2 diabetic patients. This is because it decreases the hepatic glucose output and acts as…
Pemphigus foliaceus masquerading as IgA pemphigus and responding to dapsone
A 14-year-old male presented with seven years history of recurrent episodes of fluid filled, itchy and eroded lesions over the body not responding to oral corticosteroids and azathioprine. Dermatological examination revealed crusted plaques and erosions in a seborrheic distribution. Histopathology…
Tagi: Dapsone, IgA, IgA pemphigus, pemphigus, pemphigus foliaceus
Napisano w Around the Globe, News and Information
Napisano w Around the Globe, News and Information
Acantholysis revisited: Back to basics
Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders. Although a well-known concept, the…
Tagi: acantholysis, Nikolsky′s sign, primary, secondary
Napisano w Around the Globe, News and Information
Napisano w Around the Globe, News and Information
Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis
The authors present their experience related to the diagnosis, traktowanie, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, i 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis…
