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Arquivos Mensais: May 2012

Clinical Features and Practical Diagnosis of Bullous Pemphigoid

Bullous pemphigoid (BP) represents the most common autoimmune subepidermal blistering disease. BP typically affects the elderly and is associated with significant morbidity. It has usually a chronic course with spontaneous exacerbations. The cutaneous manifestations of BP can be extremely protean.

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Pemphigus vulgaris treated with adalimumab: case study

ABSTRACT The study describes the case of a patient with a clinical and histopathological diagnosis of pemphigus vulgaris accompanied by severe side‚Äźeffects of combined immunosuppressive therapy, who achieved a remission of the disease with adalimumab. Pemphigus vulgaris is a chronic

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Mycophenolate Mofetil for the Management of Autoimmune Bullous Diseases

This article reviews the use of MMF for the treatment of several bullous conditions, and assesses the evidence gathered from clinical trials and case series. According to numerous case series, MMF could be of value in treating refractory disease.

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Pathogenesis of Bullous Pemphigoid

Bullous pemphigoid, the most common autoimmune blistering disease, is induced by autoantibodies against type XVII collagen. Passive transfer of IgG or IgE antibodies against type XVII collagen into animals has revealed not only the pathogenicity of these antibodies but also

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Diagnosis and Clinical Features of Pemphigus Vulgaris

Autoimmune bullous diseases are associated with autoimmunity against structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include those where the skin blisters at the basement membrane zone and those where the skin

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Azathioprine in the treatment of Autoimmune Blistering diseases

Although there are no standard guidelines for the treatment of autoimmune blistering diseases, azathioprine has shown good efficacy in acquired autoimmune blistering diseases, and is well tolerated. Side effects of azathioprine normally occur in mild variants. Severe reactions are due

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