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Enrichment of total serum IgG4 in pemphigus patients.

Background:  Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein adhesion proteins. Previous studies have shown an IgG4>IgG1 predominance of anti-desmoglein antibodies in pemphigus; however, no studies have examined total serum IgG4

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The P/P Registry has been approved by the Western Institutional Review Board (WIRB) and is actively enrolling participants.

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