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Randomized controlled study to evaluate CellCept in the treatment of pemphigus vulgaris.


Aspreva Pharmaceuticals Corporation is currently working to provide more evidence-based Medicines for less common diseases. The company recently announced the initiation of a Phase III trial to evaluate the safety and efficacy of CellCept (mycophenolate mofetil) with corticosteroids to achieve remission in patients with pemphigus vulgaris. The randomized double-blind, placebo-controlled trial will evaluate mycophenolate mofetil in 77 patients with active pemphigus vulgaris over 52 weeks. The primary endpoint of this study is defined as minimally active disease (no persistent or new lesions) with CellCept and low-dose Steroid. The study will be completed in 2007.

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CASE OF THE MONTH.

BANFF, ALTA. — Pemphigus vulgaris is rare in childhood, Dr. Jeffrey Callen said in a poster session at the annual meeting of the Society for Pediatric Dermatology. The disease usually occurs between 40 and 60 years of age. Dermatologically, oral ……

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Pemphigus vulgaris.

A recent study published in the Archives of Dermatology evaluated adjuvant therapy with oral dexamethasone pulse therapy in the treatment of pemphigus vulgaris. (2) This randomized, multi-center, placebo-controlled trial evaluated 20 patients with new pemphigus vulgaris. Patients were randomized to ……

Abstract Pemphigus Foliaceus (PF) is an antibody-mediated autoimmune disease. IgG directed against desmoglein-1 induces acantholysis in the superficial epidermis, leading to the classic presentation of crusted erosions in a seborrheic distribution. We report a case of a 51-year-old African-American man ……

The authors in this study injected littermates of neonatal athymic nude mice with pemphigus vulgaris (PV) to determine whether a cholinergic agonist can abolish PV IgG-induced acantholysis. Previous studies have determined the importance of cholinergic receptors in the pathogenesis of ……

CellCept (mycophenolate mofetil capsules and tablets).

CellCept Oral Suspension (mycophenolate mofetil for oral suspension) CellCept Intravenous (mycophenolate mofetil hydrochloride for injection) PRECAUTIONS Drug Interactions Initial Paragraph Sevelamer, Norfloxacin, and Metronidazole (drugs added) Cyclosporine In renal transplant patients, mean MPA exposure (AUC0-12h)……

Oral mycophenolate mofetil looks promising for lupus nephritis.

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Know Cutaneous Signs of Internal Malignancies.
SEA ISLAND, GA. — Manyofthe7%15% of patients with internal malignancy who develop cutaneous paraneoplasias will seek care for these dermatologic conditions first, so family physicians should be alert to their significance for early diagnosis, Dr. Toni L. McCullough said at ……

Infliximab for the treatment of severe steroid refractory acute graft-versus-host disease in three patients after allogeneic hematopoietic transplantation.
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Youth, mucosal disease predict pemphigus relapse.

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IVIg for refractory pemphigus. (Steroid-Resistant Disease).

NEW ORLEANSIntravenous immunoglobulin helped to get pemphigus under control in patients with disease refractory to systemic steroids. In two studies, 15 patients with moderate to severe pemphigus vulgaris and 7 patients with severe pemphigus foliaceus experienced significant improvement ……

NEW ORLEANSData are piling up in favor of two experimental treatments for patients with pemphigus. Mycophenolate mofetil and intravenous immunoglobulin (IVIg) appear to provide pemphigus patients with a welcome alternative to systemic steroids and a chance to finally ……

CellCept[R] (mycophenolate mofetil) in pemphigus vulgaris.
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