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Is there an emergent need to modify the Desmoglein compensation theory in pemphigus on the basis of ELISA data and alternative pathogenic mechanisms ?

We read with interest the study by Koga H et al1 and we believe that in light of recent observations including our data (Table 1) the “desmoglein compensation theory” as a explanation for localization of blisters should be revisited 2,3,4.

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Опубликовано в Around the Globe, News and Information

Autoantibody detection in bullous pemphigoid: Clinical evaluation of the EUROPLUS™ Dermatology Mosaic.

Bullous pemphigoid (BP) is an autoimmune blistering skin disease. Autoantibodies to BP180 and BP230 can be detected by indirect immunofluorescence (IIF) on different substrates (oesophagus, salt-split-skin, BP180-antigen dots, BP230-transfected cells) and ELISA. Here, we compared test characteristics of these test

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Опубликовано в Around the Globe, News and Information

Diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-skin autoantibodies in autoimmune blistering skin diseases: A systematic review and meta-analysis.

Abstract BACKGROUND: Systematic reviews and meta-analysis are essential tools to accurately and reliably summarize evidence, and can be used as a starting point for developing practice guidelines for the diagnosis and treatment of patients. AIM: To estimate the diagnostic accuracy

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Опубликовано в Around the Globe, News and Information

Pemphigus: An Acronym for a Disease with Multiple Causes

by Sarah Brenner, MD, Jacob Mashiah, MD, Einat Tamir, MD, Ilan Goldberg, MD and Yonit Wohl, MD, Department of Dermatology, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Israel Pemphigus is generally considered to stem

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Опубликовано в Medical

Pemphigus & Ocular Involvement: A Survey

by Edward Tenner, M.D. INTRODUCTION The autoimmune bullous skin diseases, pemphigus (with major subsets pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus) and the more common bullous pemphigoid (with variant disease phenotypes of cicatricial pemphigoid and gestational pemphigoid) each may have

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Опубликовано в Medical

Pemphigus: A Historical Perspective

By Robert Jordon, M.D.Professor and Chairman, Department of Dermatology,University of TexasHouston, Texas Historical Perspective The term pemphigus was most likely in use in the ancient world, but the first recorded instance was by Hippocrates (460-370 BC) who described pemphigoid fever

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Опубликовано в Medical

Pemphigus Ethnicity & ELISA Studies

By Professor Martin M Black, MD Pemphigus and its variants are rare autoimmune disorders characterized by loss of cell to cell cohesion between keratinocytes leading to intra-epidermal blistering. In all types of pemphigus, antibodies are directed against antigens in the

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Опубликовано в Medical

Cicatricial Pemphigoid Has Numerous Manifestations

by Dr. Joyce Rico Cicatricial pemphigoid is an autoimmune blistering disease that predominately effects mucous membranes, including the mouth and throat, eyes, and genitalia. Patients with skin involvement present with tense blisters or erosion, often on the head and neck,

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Опубликовано в Medical

Companion Animals, Too, Can Get Pemphigus

by Thierry Olivry, DrVet, PhD, DipACVD, DipECVD, Associate Professor of Dermatology, Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, North Carolina, and Adjunct Clinical Associate Professor of Dermatology, Department of Dermatology, School of Medicine, University of

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Опубликовано в Medical

Why Lesions Occur at Different Sites

By Grant J. Anhalt, M.D. Johns Hopkins Dermatology I will attempt to clarify what we know about the antibody response in various forms of pemphigus and how the distribution of the targeted antigens affects the location of lesions. The synthesis

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Опубликовано в Medical
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