Tag Archives: Autoimmune bullous diseases

<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-360">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-359">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-358">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-357">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-356">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-355">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-354">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-353">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-352">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-351">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-350">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-349">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-348">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-347">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-344">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-343">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-341">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-340">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-339">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-337">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-336">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-334">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-333">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-332">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-330">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-329">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-328">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-327">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-324">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-323">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-322">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-321">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-320">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-319">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-318">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-317">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-310">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-309">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-307">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-306">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-305">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-304">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-303">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-299">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-296">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-295">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-294">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-293">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-292">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-291">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-290">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-289">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-288">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-287">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-286">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-285">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-284">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-283">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-282">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-281">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-279">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-278">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-276">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-275">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-274">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-273">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-272">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-271">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-270">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-269">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-267">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-266">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-265">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-263">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-262">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-261">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-260">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-259">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-258">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-257">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-256">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-255">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-254">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-253">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-252">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-251">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-247">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-245">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-244">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-243">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-242">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-241">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-240">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-239">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-237">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-236">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-235">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-234">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-233">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-232">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-231">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-230">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-229">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-228">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-227">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-226">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-225">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-224">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-223">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-222">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-221">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-220">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-219">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-218">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-217">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-216">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-215">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-214">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-213">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-212">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-211">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-210">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-209">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-208">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-206">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-202">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-201">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-186">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-185">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-184">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-183">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-182">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-181">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-180">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-179">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-178">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-177">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-172">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-171">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-170">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-169">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-163">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-162">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-161">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-134">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-123">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-119">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-118">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-115">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-114">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-113">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-110">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-103">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-86">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-85">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-84">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-18">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-17">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-16">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-3">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-2">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-1">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-0">div class="row">
IMPORTANCE A rare variant of mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 (Lam332) autoantibodies and seems to be associated with concurrent malignant neoplasms.

OBJECTIVE To determine the prevalence and clinical significance of anti-Lam332 autoantibody detection from a large series of patients with MMP. DESIGN Multicenter retrospective study.

SETTING Four French national centers for autoimmune bullous diseases.

PARTICIPANTS One hundred fifty-four patients with MMP and 89 individuals serving as controls were included.

INTERVENTIONS Serum samples were analyzed by a new Lam332 enzyme-linked immunosorbent assay (ELISA); clinical and immunopathologic data were obtained from the patients’ medical records.

MAIN OUTCOME MEASURES The Lam332 ELISA scores were evaluated with respect to clinical characteristics, standard and salt-split indirect immunofluorescence, and bullous pemphigoid (BP) 230 and BP180-NC16A ELISAs.

RESULTS The Lam332 ELISA score was positive (≥9 U/mL) in 20.1% of serum samples from patients with MMP, 1 of 50 patients with bullous pemphigoid (BP), none of 7 with pemphigus, and 3 of 32 other controls. No relationship was evidenced between a positive ELISA Lam332 score and age; sex ratio; oral, ocular, genital, skin, or esophageal/laryngeal involvement; internal malignant neoplasm; or BP180 ELISA score. Salt-split skin indirect immunofluorescence and ELISA BP230 results were more frequently positive when Lam332 ELISA results were positive (P = .04 and .02, respectively). Patients with a positive Lam332 ELISA score frequently had more severe MMP (67.8% vs 47.2%; P = .04).

CONCLUSIONS AND RELEVANCE Results of this novel ELISA showed that serum anti-Lam332 autoantibodies are detected in 20.1% of patients with MMP. Anti-Lam332 autoantibodies are mainly detected in patients with severe MMP but not preferentially in those with a malignant neoplasm. The association between anti-Lam332 and anti-BP230 autoantibodies might arise from an epitope-spreading phenomenon.

JAMA dermatology (Chicago, Ill.)

<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-360">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-359">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-358">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-357">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-356">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-355">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-354">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-353">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-352">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-351">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-350">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-349">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-348">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-347">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-344">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-343">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-341">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-340">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-339">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-337">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-336">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-334">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-333">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-332">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-330">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-329">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-328">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-327">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-324">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-323">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-322">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-321">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-320">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-319">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-318">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-317">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-310">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-309">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-307">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-306">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-305">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-304">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-303">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-299">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-296">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-295">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-294">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-293">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-292">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-291">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-290">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-289">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-288">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-287">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-286">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-285">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-284">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-283">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-282">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-281">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-279">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-278">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-276">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-275">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-274">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-273">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-272">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-271">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-270">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-269">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-267">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-266">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-265">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-263">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-262">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-261">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-260">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-259">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-258">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-257">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-256">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-255">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-254">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-253">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-252">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-251">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-247">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-245">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-244">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-243">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-242">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-241">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-240">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-239">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-237">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-236">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-235">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-234">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-233">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-232">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-231">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-230">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-229">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-228">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-227">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-226">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-225">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-224">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-223">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-222">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-221">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-220">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-219">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-218">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-217">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-216">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-215">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-214">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-213">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-212">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-211">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-210">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-209">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-208">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-206">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-202">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-201">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-186">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-185">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-184">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-183">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-182">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-181">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-180">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-179">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-178">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-177">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-172">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-171">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-170">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-169">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-163">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-162">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-161">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-134">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-123">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-119">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-118">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-115">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-114">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-113">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-110">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-103">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-86">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-85">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-84">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-18">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-17">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-16">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-3">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-2">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-1">span class="explanatory-dictionary-highlight" data-definition="explanatory-dictionary-definition-0">div class="row">
Pemphigus is a potentially fatal autoimmune epidermal bullous disorder. Rituximab is a novel therapy for the treatment of refractory pemphigus. However, there is limited clinical data on safety and efficacy of rituximab in pediatric age group. Herein, we report an 11-year-old boy of childhood pemphigus vulgaris who failed to respond to dexamethasone pulse therapy and was subsequently treated with rituximab and achieved complete remission.

http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=5;spage=632;epage=634;aulast=Kanwar