The International Pemphigus & Pemphigoid Foundation and Dr. Sarah Brenner recently conducted a survey on some aspects of pemphigus, in particular the gender distribution of the patients, and the relationship between the disease and the use of sex hormones.
This Plan takes us a giant step closer to getting additional funding for autoimmune disease research. Congressional approval is now needed to implement and fund the Plan. The Foundation is asking everyone to advocate for this Plan by contacting their Senators and Representatives and urging them to support it. This effort is being coordinated by the American Autoimmune Related Diseases Association (AARDA), which worked closely with NIH on the development of the Plan. Virginia Ladd, Executive Director of AARDA, said: “It is important for all patients with any autoimmune disease to fight for funding for this plan. Supporting autoimmune disease research will help all patients, regardless of their particular illness.”
by Luis A. Diaz, M.D.
Professor and Chairman Department of Dermatology Medical College of Wisconsin
Pemphigus foliaceous (PF) one of the major clinical variants of pemphigus, is characterized by superficial blisters and anti-epidermal autoantibodies. The epidermal antigen with which PF autoantibodies react is a desmosomal protein designated desmoglein 1 (dsg1). There are two forms of PF-a sporadic form which has worldwide distribution, and an endemic form, which has only been observed in certain rural areas of Brazil, Columbia and Tunisia.