Tag Archives: glucocorticoid

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By Sergei A. Grando, MD, PhD, DSci
Professor of Dermatology
University of California Davis

The Need for Alternative Therapies for Pemphigus. In autoimmune pemphigus, systemic glucocorticosteroid treatment is life saving but may cause severe side effects. Pemphigus patients therefore need drugs that will provide safer treatment of their disease by replacing systemic use of glucocorticoid hormones such as Prednisone. Development of non-hormonal treatment is hampered by a lack of clear understanding of the mechanisms leading to pemphigus lesions. Pemphigus can be associated with myasthenia gravis, and in both diseases the autoantibodies to acetylcholine receptors are produced, suggesting a common mechanism of disease development.

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Active Imageby Victoria Werth, M.D.,
Assistant Professor Dermatology
University of Pennsylvania
Chief Dermatology Section
Philadelphia Veterans Administration Hospital
Philadelphia, PA

 Systemically administered glucocorticoids are potent immunosuppressive and anti-inflamatory drugs that play an important role in treating many dermatologic disorders, including the different types of pemphigus. Unfortunately, their potency also results in numerous side effects, many of which can be minimized by attention to a few details.