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by Ernest H. Beutner, Ph.D.*
Professor of Microbiology and Dermatology,
University of Buffalo; School of Medicine and Biomedical Sciences;
Buffalo, NY

Patients with pemphigus may benefit by working with their doctors to gain a better understanding of the tests used to detect and control the disease, in some situations. Three groups of tests can help doctors diagnose pemphigus; one of these can also help to control the disease. Two groups use skin or oral tissue samples, one from light microscopy and one for direct immunofluorescence. A third group uses blood tests for the pemphigus antibodies that cause the disease; these fluctuate with disease activity. Many doctors use al three methods to check all diagnoses of pemphigus; each test gives different types of information.