Espiritu ng dapsone sa paggamot ng pempigus at pemphigoid: pagsusuri ng mga kasalukuyang data.

Dapsone ay isang chemotherapeutic na na ahente na pangunahing ginagamit sa gamot ketong, Pneumocystis jiroveci (dati carinii) pulmonya, at malarya. Din ito ay ginamit bilang isang katulong sa paggamot ng pempigus at pemphigoid.

To assess the role of dapsone in the treatment of pemphigus and pemphigoid, a retrospective review of reports in the English-language literature was conducted. Information on the number of patients treated, their average age, prior therapies, indications for use, protocol (dose and interval) used, concomitant therapies, reported adverse effects, and clinical outcomes were analyzed. May mga 35 case reports/series published describing the use of dapsone in a total of 427 pasyente. Data on 55 pemphigus patients were obtained from several case reports and some case series and one randomized controlled trial. Ng mga, 32 mga pasyente na may pempigus vulgaris at 14 patients with pemphigus foliaceus responded to dapsone. Data from 13 kaso serye, each including at least five patients, accounted for 372 patients with pemphigoid. The overall response rates to dapsone, when given either alone or in combination with corticosteroids or immunosuppressive agents, ay 84% in mucous membrane pemphigoid, at 81% sa bullous pemphigoid. Hemolysis was the most common adverse effect observed. Dapsone is a promising and useful agent in patients with autoimmune mucocutaneous blistering diseases, especially in mucous membrane pemphigoid. It can be used as a corticosteroid-sparing agent. Kaya, its combined use with oral corticosteroids may be useful in pemphigus vulgaris and bullous pemphigoid. Adverse effects of dapsone are dose dependent and usually reversible. Hemolysis and concomitant anemia secondary to hemolysis are expected in most patients. In the opinion of the authors, dapsone is underutilized in the treatment of autoimmune mucocutaneous blistering diseases.