Roche Holding AG (ROG)’s top-selling drug Rituxan effectively cured most cases of a rare and deadly skin disease in a patient study that suggests the medicine may replace steroids as the standard treatment. In a trial among 22 people with…
Blog Archives
Roche’s Rituxan Cures Rare Skin-Blistering Disease in Study
Tagged with: immune system, lesions, Medicine, patients, pemphigus, rituxan, rituximab, Roche, steroids
Posted in Around the Globe, News and Information, Treatment and Medication
Posted in Around the Globe, News and Information, Treatment and Medication
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity.
Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this…
Oral Inflammation in Small Animals
The oral cavity can be affected by a wide variety of disorders characterized by inflammation of the gingiva and/or oral mucosa. In dogs and cats, differential diagnoses for generalized oral inflammatory disorders include plaque-reactive mucositis, chronic gingivostomatitis, eosinophilic granuloma complex,…
Tagged with: Canine, cat, chronic gingivostomatitis, dog, eosinophilic granuloma complex, erythema multiforme, feline, pemphigoid, pemphigus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
The frequency of osteoporosis in patients with pemphigus vulgaris on treatment
Background: Pemphigus vulgaris was almost fatal before the advent of glucocorticoids. Unfortunately, the high doses and prolonged administration of glucocorticoids, which often needed to control the disease, result in numerous adverse effects many of which are serious. Aims: To evaluate the patients…
Tagged with: glucocorticoids, osteoporosis, pemphigus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Desmosomal adhesion and pemphigus vulgaris: the first half of the story
Pemphigus vulgaris (PV) is a paradigm of autoimmune disease affecting intercellular adhesion. The mechanisms that lead to cell–cell detachment (acantholysis) have crucial therapeutic implications and are currently undergoing major scrutiny. The first part of this review focuses on the classical…
Oxidative stress and autoimmune skin disease.
Antioxidants play the important role in our body of neutralizing free radicals and peroxides that are formed during normal physiologic events. While these reactive oxygen species are necessary for numerous biological processes, when created in excess they can have deleterious…
Tagged with: alopecia areata, Oxidative stress, pemphigus, pemphigus vulgaris, psoriasis, vitiligo
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Lobar torsion after lung transplantation
Lobar torsion is a rare complication after lung transplantation. Here we report a case of right middle lobe (RML) torsion after bilateral sequential lung transplantation (BLTx). This 30-year-old lady underwent BLTx for bronchiolitis obliterans due to paraneoplastic pemphigus. The right…
Tagged with: extracorporeal membrane oxygenation, lung transplantation, pemphigus, torsion abnormality
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Drug-triggered pemphigus foliaceus
Pemphigus foliaceus (PF) is the most common autoimmune skin disease of dogs and other animal species. Although PF can spontaneously affect dogs of any breed, it appears more prevalent in Akita Inus and chow chows in the United States. The…
Endemic pemphigus in the peruvian Amazon: epidemiology and risk factors for the development of complications during treatment
BACKGROUND: Pemphigus is an autoimmune blistering disease. According to a report, in areas of endemic pemphigus foliaceus (EPF) in Peru there are cases of pemphigus vulgaris with epidemiologic, clinical and histopathologic characteristics similar to those of “endemic pemphigus vulgaris” (EPV) in…
Pemphigus foliaceus masquerading as IgA pemphigus and responding to dapsone
A 14-year-old male presented with seven years history of recurrent episodes of fluid filled, itchy and eroded lesions over the body not responding to oral corticosteroids and azathioprine. Dermatological examination revealed crusted plaques and erosions in a seborrheic distribution. Histopathology…
Tagged with: Dapsone, IgA, IgA pemphigus, pemphigus, pemphigus foliaceus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
