Q. What is pemphigus? What is the best treatment? A. Pemphigus is a general term that describes four different disease entities, which we refer to as the Pemphigus Complex, primarily limited to the skin. All are considered to be immune mediated diseases.…
Blog Archives
Pemphigus in Cats
Tagged with: cat, dermatology, pemphigus, veterinarian
Posted in Around the Globe, News and Information, Treatment and Medication
Posted in Around the Globe, News and Information, Treatment and Medication
Rituximab in pemphigus
Pemphigus is a chronic, muco-cutaneous autoimmune blistering disorder; two main variants being pemphigus vulgaris (PV) and pemphigus foliaceus (PF). PV is the most common subtype, varying between 75 to 92% of total pemphigus patients. Although no community based studies are undertaken…
Tagged with: corticosteroid, DCP, IgG1, immunosuppressant, MabThera, pemphigus, pemphigus foliaceus, pemphigus vulgaris, rituxmab
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus
We evaluated the effectiveness of mizoribine, a newly developed immunosuppressive agent, as an adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. Eleven pemphigus patients (eight pemphigus vulgaris and three pemphigus foliaceus) received the combination therapy of…
Tagged with: blood concentration level, corticosteroids, immunosuppressive agent, mizorbine, mizoribine, pemphigus, pemphigus foliaceus, prednisolone
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Is there an emergent need to modify the Desmoglein compensation theory in pemphigus on the basis of ELISA data and alternative pathogenic mechanisms ?
We read with interest the study by Koga H et al and we believe that in light of recent observations including our data the “desmoglein compensation theory” as a explanation for localization of blisters should be revisited. Although the disruption…
Tagged with: autoantibodies, desmoglein, pemphigus, theory
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Efficacy of low-dose rituximab in a refractory acquired factor VIII inhibitor case secondary to pemphigus.
Acquired factor VIII (FVIII) inhibitor induces a bleeding disorder caused by specific antibodies to FVIII. The cause of approximately one fifth of cases can be attributed to autoimmune disorders, such as pemphigus. Here, we describe a case of refractory acquired…
Tagged with: cyclosporine, FVIII, pemphigus, prednisolone, rituxmab
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Lack of relationship between blood groups and clinical outcome (body surface area affected) in patients with pemphigus vulgaris
Associations between blood groups and several diseases are observed in the literature. Some of these have scientific support suggesting a rationale, statistical relation. The association between ABO groups with several malignancies, hypercholesterolemia, thrombosis, myocardial infarction, duodenal ulcer, infections, and autoimmune…
Tagged with: blood, pemphigus, pemphigus vulgaris, tests
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Ultrastructure of acantholysis in pemphigus foliaceus reexamined from the current perspective.
Background Pemphigus foliaceus (PF) is a chronic cutaneous autoimmune blistering disease that is characterized by superficial blistering of the skin, and according to the current perspective is caused by autoantibodies directed against desmoglein 1 (Dsg1). Objectives To examine early acantholysis…
Tagged with: desmosomes, pemphigus, pemphigus foliaceus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Is there an emergent need to modify the Desmoglein compensation theory in pemphigus on the basis of ELISA data and alternative pathogenic mechanisms ?
We read with interest the study by Koga H et al1 and we believe that in light of recent observations including our data (Table 1) the “desmoglein compensation theory” as a explanation for localization of blisters should be revisited 2,3,4.…
Tagged with: autoantibodies, library, pathophysiology, pemphigus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
Enrichment of total serum IgG4 in pemphigus patients.
Background: Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein adhesion proteins. Previous studies have shown an IgG4>IgG1 predominance of anti-desmoglein antibodies in pemphigus; however, no studies have examined total serum IgG4…
Tagged with: anti-desmoglein, antibodies, IgG4, pemphigus
Posted in Around the Globe, News and Information
Posted in Around the Globe, News and Information
IgA pemphigus associated with diffuse large B-cell lymphoma showing unique reactivity with desmocollins: Unusual clinical and histopathological features.
Authors: Asahina A, Koga H, Suzuki Y, Hashimoto T Abstract IgA pemphigus includes subcorneal pustular dermatosis (SPD)-type and intraepidermal neutrophilic IgA dermatosis (IEN)-type. Cases of IgG/IgA pemphigus have recently been documented(1) . Nonetheless, individual reports of IgA pemphigus indicate considerable…
