Background. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune vesicobullous disorders with IgG autoantibodies directed against desmoglein (Dsg)1 and 3, which lead to intraepidermal acantholysis. Aim. To characterize the clinical and immunological profile of patients with PF or PV with umbilical…
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Neuromyelitis optica in a patient with pemphigus foliaceus
Neuromyelitis optica (NMO, also eponymously known as Devic’s disease) is an immune‐mediated demyelinating disease of the central nervous system that can lead to significant disability. Pediatric NMO is a rare disorder often reported after an infection. The authors report a…
Cyclophosphamide Trial Conclusions
Randomized open comparative trial of dexamethasone-cyclophosphamide pulse and daily oral cyclophosphamide versus cyclophosphamide pulse and daily oral prednisolone in pemphigus vulgaris.
文章分类 临床试验
Trial for New Lupus Treatment Is Called Promising
A medicine to treat lupus has proved effective in a large clinical trial, which could pave the way for approval of the first new treatment for the disease in more than 40 years. In recent years, many other companies have…
文章分类 临床试验
Interventions for pemphigus vulgaris and pemphigus foliaceus
This review of clinical trials aimed to find out which is the most effective and safest treatment option for pemphigus vulgaris and pemphigus foliaceus.
文章分类 临床试验
Use of Infliximab for the Treatment of Pemphigus Vulgaris
This study will determine if infliximab given in combination with prednisone is a safe and effective treatment for adults with PV.
文章分类 临床试验
Clinical Trials with IVIG and Cyclophosphamide
One of the newest treatments for pemphigus is intravenous immunoglobulin (IVIG). Immunoglobulins are one of the major classes of proteins in blood. IVIG is collected from normal blood donors, pooled, highly purified, and treated to destroy viruses and bacteria. IVIG…
文章分类 临床试验, Issue 54 - Fall 2008
The use of KC706 for the Treatment of Pemphigus Vulgaris
The purpose of this trial is to (a) determine the ability of KC706 to prevent the appearance of new blisters and heal existing blisters, while maintaining stable doses of corticosteroids and/or immunosuppressants, in patients with pemphigus vulgaris (b) to determine…
文章分类 临床试验
UPENN Clinical Trial
A Study to Evaluate the Intra-rater and Inter-rater reliability of the Pemphigus Disease Area Index (PDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) for Use by Dermatologists To download and print the Informed Consent Form, click HERE. (You will…
文章分类 临床试验
NYU: Is IVIg Effectiveness Improved by the Concurrent Administration of Cyclophosphamide
The purpose of the trial is to determine whether the effectiveness of IVIg is improved by the concurrent administration of cyclophosphamide. There is evidence that it can, but a formal randomized trial is required to be sure.
文章分类 临床试验
